2026-06-14T03:29:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/229822024-11-28T21:18:15Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
de la Rica, Roberto
author
Borges Sa, Marcio
author
Aranda Perez, Maria
author
del Castillo Blanco, Alberto
author
Socias Mir, Antonia
author
Payeras Cifre, Antonio
author
Rialp, Gemma
author
Socias Crespi, Lorenzo
author
Masmiquel Comas, Lluis
author
Gonzalez-Freire, Marta
2024-09-13T09:14:48Z
2024-09-13T09:14:48Z
2020-08
De la Rica R, Borges Sa M, Aranda M, Del Castillo Blanco A, Socias Mir A, Payeras Cifre A, et al. Low Albumin Levels Are Associated with Poorer Outcomes in a Case Series of COVID-19 Patients in Spain: A Retrospective Cohort Study. Microorganisms. 2020 Aug;8(8):1106.
10.3390/microorganisms8081106
2076-2607
Microorganisms
http://hdl.handle.net/20.500.13003/9909
32722020
2-s2.0-85090671889
https://hdl.handle.net/20.500.12105/22982
567059300001
There is limited information available describing the clinical and epidemiological features of Spanish patients requiring hospitalization for coronavirus disease 2019 (COVID-19). In this observational study, we aimed to describe the clinical characteristics and epidemiological features of severe (non-ICU) and critically patients (ICU) with COVID-19 at triage, prior to hospitalization. Forty-eight patients (27 non-ICU and 21 ICU) with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were analyzed (mean age, 66 years, [range, 33-88 years]; 67% males). There were no differences in age or sex among groups. Initial symptoms included fever (100%), coughing (85%), dyspnea (76%), diarrhea (42%) and asthenia (21%). ICU patients had a higher prevalence of dyspnea compared to non-ICU patients (95% vs. 61%,p= 0.022). ICU-patients had lymphopenia as well as hypoalbuminemia. Lactate dehydrogenase (LDH), C-reactive protein (CRP), and procalcitonin were significantly higher in ICU patients compared to non-ICU (p< 0.001). Lower albumin levels were associated with poor prognosis measured as longer hospital length (r = -0.472,p< 0.001) and mortality (r = -0.424,p= 0.003). As of 28 April 2020, 10 patients (8 ICU and 2 non-ICU) have died (21% mortality), and while 100% of the non-ICU patients have been discharged, 33% of the ICU patients still remained hospitalized (5 in ICU and 2 had been transferred to ward). Critically ill patients with COVID-19 present lymphopenia, hypoalbuminemia and high levels of inflammation.
eng
COVID-19
Albumin
Inflammation
Low Albumin Levels Are Associated with Poorer Outcomes in a Case Series of COVID-19 Patients in Spain: A Retrospective Cohort Study
research article