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oai:repisalud.isciii.es:20.500.12105/229762024-11-29T02:18:52Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Capó Fiol, Xavier author Ferrer, Miguel D author Olek, Robert A author Salaberry, Eduardo author Suau, Rafael author Mari, Bartolome author Llompart Alabern, Isabel author Tur, Josep A author Soldevila Verdeguer, Carla author Pons, Antoni author 2020-07 The beneficial effects of exercise for the treatment and prevention of metabolic syndrome pathologies have been related to its anti-inflammatory and antioxidant effects. Dietary nitrate supplementation is an emerging treatment strategy to alleviate the symptoms of metabolic syndrome affections and to improve vascular function. In this double-blind crossover trial, metabolic syndrome patients performed two exercise tests for 30 min at 60-70% maximal heart rate after the intake of a placebo or a nitrate-enriched beverage. Acute exercise increased the plasma concentration of TNF alpha, intercellular adhesion molecule ICAM1, PGE1, PGE2 and the newly detected 16-hydroxypalmitic acid (16-HPAL) in metabolic syndrome patients. The cytokine and oxylipin production by peripheral blood mononuclear cells (PBMCs) and neutrophils could be responsible for the plasma concentrations of TNF alpha and IL6, but not for the plasma concentration of oxylipins nor its post-exercise increase. The intake of sodium nitrate 30 min before exercise increased the concentration of nitrate and nitrite in the oral cavity and plasma and reduced the oxygen cost of exercise. Additionally, nitrate intake prevented the enhancing effects of acute exercise on the plasma concentration of TNF alpha, ICAM1, PGE1, PGE2 and 16-HPAL, while reducing the capabilities of PBMCs and neutrophils to produce oxylipins. Capo X, Ferrer MD, Olek R A, Salaberry E, Suau R, Mari B, et al. Oral Administration of Sodium Nitrate to Metabolic Syndrome Patients Attenuates Mild Inflammatory and Oxidative Responses to Acute Exercise. Antioxidants. 2020 Jul;9(7):596. 10.3390/antiox9070596 2076-3921 Antioxidants http://hdl.handle.net/20.500.13003/10198 32646062 2-s2.0-85087569839 https://hdl.handle.net/20.500.12105/22976 557148800001 Exercise Inflammation Metabolic syndrome Nitrate Oxidative stress Supplementation Oral Administration of Sodium Nitrate to Metabolic Syndrome Patients Attenuates Mild Inflammatory and Oxidative Responses to Acute Exercise