2026-07-21T11:39:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/229752024-11-29T05:17:04Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Hernández, Yumaira
author
Costa-Bauza, Antonia
author
Calvó García, Paula
author
Benejam Gual, Joan Maria
author
Sanchis, Pilar
author
Grases, Felix
2024-09-13T09:14:45Z
2024-09-13T09:14:45Z
2020-07
Hernandez Y, Costa-Bauza A, Calvo P, Benejam J, Sanchis P, Grases F. Comparison of Two Dietary Supplements for Treatment of Uric Acid Renal Lithiasis: Citrate vs. Citrate plus Theobromine. Nutrients. 2020 Jul;12(7):2012.
10.3390/nu12072012
2072-6643
Nutrients
http://hdl.handle.net/20.500.13003/10187
32645831
L2004673791
2-s2.0-85087802036
https://hdl.handle.net/20.500.12105/22975
558645600001
Background. Uric acid (UA) renal lithiasis has a high rate of recurrence and a prevalence ranging from 10% and 15%, depending on the population. The most important etiological factor is persistence of urinary pH below 5.5 and one of the most common treatments is alkalization with citrate. Recent studies demonstrated that theobromine, which is abundant in chocolate and cocoa, is a potent inhibitor of UA crystallization. Aim. The aim was to compare the efficacy of citrate versus citrate + theobromine as treatment for UA lithiasis. Methods. This randomized cross-over trial investigated the efficacy of two treatments in 47 patients with UA renal lithiasis. Urine volume, pH, UA excretion, theobromine excretion, and risk of UA crystallization (RUAC) at baseline and at the end of each intervention period were measured. Results. Each treatment significantly reduced the risk of UA crystallization compared to basal values. The RUAC after citrate + theobromine was lower than the RUAC after citrate, although this difference was not statistically significant. Conclusion. The combined consumption of citrate and theobromine may be a promising strategy for the prevention of UA kidney stones.
eng
Uric acid
Urolithiasis
Theobromine
Dietary treatment
Comparison of Two Dietary Supplements for Treatment of Uric Acid Renal Lithiasis: Citrate vs. Citrate plus Theobromine
research article