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oai:repisalud.isciii.es:20.500.12105/229732024-11-29T00:03:46Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Sanchis, Pilar author Rivera Irigoin, Rosmeri author Fortuny Marques, Regina author Rio-Bocos, Carlos author Mas-Gelabert, Miguel author Gonzalez-Freire, Marta author Grases, Felix author Masmiquel Comas, Lluis author 2020-06-05 The aim of this study was to evaluate the relationship between serum levels of advanced glycation end products (AGEs) and abdominal aortic calcification (AAC) in patients with type 2 diabetes mellitus (DM2). This was a prospective cross-sectional study. One-hundred and four consecutive patients with DM2 were given lateral lumbar X-rays in order to quantify abdominal aortic calcification (AAC). Circulating levels of AGEs and classical cardiovascular risk factors were determined. Clinical history was also registered. Patients with higher AGEs values had higher grades of aortic calcification and higher numbers of diabetic-related complications. Multivariate logistic regression analysis showed that being older, male and having high levels of AGEs and triglycerides were the independent risk factors associated to moderate-severe AAC when compared to no-mild AAC. Our results suggest that AGEs plays a role in the pathogenesis of aortic calcifications. In addition, the measurement of AGEs levels may be useful for assessing the severity of AAC in the setting of diabetic complications. Sanchis P, Rivera R, Fortuny R, Río C, Mas-Gelabert M, Gonzalez-Freire M, et al. Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus. J Clin Med. 2020;9(6). 2077-0383 http://hdl.handle.net/20.500.13003/18494 https://hdl.handle.net/20.500.12105/22973 32516928 10.3390/jcm9061751 Journal of clinical medicine 2-s2.0-85094649366 552482100001 L2004504640 Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus