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00925njm 22002777a 4500 dc Ruiz Azcona, Laura author Roman-Rodriguez, Miguel author Llort Bove, Montserrat author van Boven, Job FM author Santibanez Marguello, Miguel author 2020-06 To determine the prevalence of influenza vaccination in chronic obstructive pulmonary disease (COPD) patients and its effect on COPD exacerbations, we conducted a retrospective population-based cohort study analyzing real-life data. We included all registered COPD patients >= 40 years old using respiratory medication during the study period (2012-2013). Influenza vaccination during the 2012/2013 campaign was the parameter studied. Moderate and severe exacerbations during 2013 were the dependent outcome variables. Logistic regression adjusting for age, gender, concomitant asthma diagnosis, COPD severity, smoking status, number of moderate and severe exacerbations the previous year, and comorbidities was performed, and 59.6% of the patients received seasonal influenza vaccination. The percentage of patients with exacerbations was higher among those vaccinated. Influenza vaccination had a statistically significantly negative (non-protective) crude effect favoring the risk of severe exacerbations: OR: 1.20 (95% CI; 1.05-1.37). This association diminished and lost statistical significance after adjustment: aOR: 0.93 (95% CI; 0.74-1.18). The protective effect in the analysis restricted to the epidemic period was not significant: aOR: 0.82 (95% CI; 0.58-1.16). We concluded that prevalence of influenza vaccination was suboptimal. In contrast with most of the available evidence, our results did not support a protective effect of influenza vaccination on the risk of admission for COPD exacerbation. Ruiz Azcona L, Román-Rodríguez M, Llort Bove M, Van Boven JFM, Santibanez Marguello M. Prevalence of Seasonal Influenza Vaccination in Chronic Obstructive Pulmonary Disease (COPD) Patients in the Balearic Islands (Spain) and Its Effect on COPD Exacerbations: A Population-Based Retrospective Cohort Study. Int J Environ Res Public Health. 2020 Jun;17(11):4027. http://hdl.handle.net/20.500.13003/10554 https://hdl.handle.net/20.500.12105/22970 32517007 10.3390/ijerph17114027 1660-4601 International Journal of Environmental Research and Public Health 2-s2.0-85086354693 542629600280 L632044652 Chronic obstructive pulmonary disease Influenza vaccination COPD exacerbations Primary prevention Prevalence of Seasonal Influenza Vaccination in Chronic Obstructive Pulmonary Disease (COPD) Patients in the Balearic Islands (Spain) and Its Effect on COPD Exacerbations: A Population-Based Retrospective Cohort Study