2026-04-27T05:20:05Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/229672024-11-28T16:46:34Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16958col_20.500.12105_16967

00925njm 22002777a 4500 dc Martinez-Delgado, Paula author Lacerenza, Serena author Obrador-Hevia, Antonia author Lopez-Alvarez, Maria author Mondaza-Hernandez, Jose L author Blanco-Alcaina, Elena author Sanchez-Bustos, Paloma author Hindi, Nadia author Moura, David S author Martin-Broto, Javier author 2020-06 Soft tissue sarcomas (STS) are a rare group of mesenchymal solid tumors with heterogeneous genetic profiles and clinical features. Systemic chemotherapy is the backbone treatment for advanced STS; however, STS frequently acquire resistance to standard therapies, which highlights the need to improve treatments and identify novel therapeutic targets. Increases in the knowledge of the molecular pathways that drive sarcomas have brought to light different molecular alterations that cause tumor initiation and progression. These findings have triggered a breakthrough of targeted therapies that are being assessed in clinical trials. Cancer stem cells (CSCs) exhibit mesenchymal stem cell (MSC) features and represent a subpopulation of tumor cells that play an important role in tumor progression, chemotherapy resistance, recurrence and metastasis. In fact, CSCs phenotypes have been identified in sarcomas, allied to drug resistance and tumorigenesis. Herein, we will review the published evidence of CSCs in STS, discussing the molecular characteristic of CSCs, the commonly used isolation techniques and the new possibilities of targeting CSCs as a way to improve STS treatment and consequently patient outcome. Martinez-Delgado P, Lacerenza S, Obrador-Hevia A, Lopez-Alvarez M, Mondaza-Hernandez JL, Blanco-Alcaina E, et al. Cancer Stem Cells in Soft-Tissue Sarcomas. Cells. 2020 Jun;9(6):1449. http://hdl.handle.net/20.500.13003/10531 http://hdl.handle.net/10668/15730 https://hdl.handle.net/20.500.12105/22967 32532153 10.3390/cells9061449 2073-4409 Cells 2-s2.0-85086602811 550759700001 L2004538391 Cancer stem cells Tumor-initiating cells Soft-tissue sarcoma Chemotherapy resistance Stemness Tumor heterogeneity Genetic and epigenetic plasticity Cancer Stem Cells in Soft-Tissue Sarcomas