2026-07-16T14:29:59Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/229632024-11-29T06:10:06Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Annunziata, Giuseppe author Jiménez-Garcia, Manuel author Tejada Gavela, Silvia author Moranta, David author Arnone, Angela author Ciampaglia, Roberto author Tenore, Gian Carlo author Soldevila Verdeguer, Carla author Novellino, Ettore author Capó Fiol, Xavier author 2020-05 A large number of studies have demonstrated the implication of oxidative stress (OxS) in the pathogenesis of ageing-related muscle decline and atrophy. The key mechanism is related to the OxS-induced production of free radicals, with the consequent increase in oxidative damage, resulting in affected muscle quality and strength. The present study aimed to evaluate the efficacy of a grape polyphenol-based nutraceutical formulation (Taurisolo(R)) in reducing the OxS in muscle of aged rats. A group of 16 aged (20 months) rats were orally administered with Taurisolo(R)(n= 8; 100 mg/kg Taurisolo(R)) or placebo (n= 8; 50 mg/kg maltodextrin); an additional group of eight young (three months) rats were also treated with placebo. All the treatments were orally administered for 30 days. The activities of antioxidant enzymes, the levels of malondialdehyde (MDA) and nitrotyrosine (N-Tyr) and the expression of OxS- and inflammation-related genes were evaluated on the gastrocnemius muscle. In muscle samples of the treated-group, increased activity of antioxidant enzymes, reduced MDA and N-Tyr levels and increased expression of antioxidant and anti-inflammatory genes were observed in respect to the placebo. Data herein presented suggest that the chronic treatment with Taurisolo(R)significantly reduces oxidative damage and improves muscle performance in aged rats. Annunziata G, Jimenez-Garcia M, Tejada S, Moranta D, Arnone A, Ciampaglia R, et al. Grape Polyphenols Ameliorate Muscle Decline Reducing Oxidative Stress and Oxidative Damage in Aged Rats. Nutrients. 2020 May;12(5):1280. 10.3390/nu12051280 2072-6643 Nutrients http://hdl.handle.net/20.500.13003/10731 32365992 L2004275829 2-s2.0-85084276918 https://hdl.handle.net/20.500.12105/22963 542272700133 Ageing Skeletal muscle Polyphenols Nutraceutical Grape Grape Polyphenols Ameliorate Muscle Decline Reducing Oxidative Stress and Oxidative Damage in Aged Rats