2026-04-29T15:24:43Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/229572024-11-28T14:51:52Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16961col_20.500.12105_16967col_20.500.12105_16968col_20.500.12105_16983
Repisalud
author
Barrubes, Laura
author
Babio, Nancy
author
Hernandez-Alonso, Pablo
author
Toledo, EstefanÃa
author
Ramirez Sabio, Judith B
author
Estruch, Ramon
author
Ros, Emilio
author
Fito, Montserrat
author
Alonso-Gomez, Angel M
author
Fiol Sala, Miquel
author
Lapetra, Jose
author
Serra-Majem, Lluis
author
Pinto, Xavier
author
Ruiz-Canela, Miguel
author
Corella, Dolores
author
Castaner, Olga
author
Macias-Gonzalez, Manuel
author
Salas-Salvado, Jordi
2024-09-13T09:14:40Z
2024-09-13T09:14:40Z
2020-04
Barrubes L, Babio N, Hernandez-Alonso P, Toledo E, Ramirez Sabio JB, Estruch R, et al. Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study. J Clin Med. 2020 Apr;9(4):1215.
10.3390/jcm9041215
2077-0383
Journal of Clinical Medicine
http://hdl.handle.net/20.500.13003/11154
32340309
L2004225718
2-s2.0-85110285108
https://hdl.handle.net/20.500.12105/22957
531821000322
Limited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other global lifestyle indices, and none in aged populations at high cardiovascular risk. We aimed to assess the association between CRC incidence and adherence to two emerging lifestyles indices (2018 WCRF/AICR score and another low-risk lifestyle (LRL) score comprising smoking status, alcohol consumption, physical activity, diet, and body mass index) in the Spanish PREvencion con DIeta MEDiterranea (PREDIMED) cohort. We studied 7216 elderly men and women at high cardiovascular risk. The 2018 WCRF/AICR and LRL scores were calculated. Multivariable Cox proportional regression models were fitted to estimate the HRs (hazard ratios) and 95% confidence intervals (CIs) for incident CRC events. During a median interquartile range (IQR) follow-up of 6.0 (4.4-7.3) years, 97 CRC events were considered. A significant linear association was observed between each 1-point increment in the WCRF/AICR score (score range from 0 to 7) and CRC risk (HR (95% CI) = 0.79 (0.63-0.99)). Similarly, each 1-point increment in the LRL score (score range from 0 to 5) was associated with a 22% reduction in CRC risk (0.78 (0.64-0.96)). Adhering to emergent lifestyle scores might substantially reduce CRC incidence in elderly individuals. Further longitudinal studies, which take different lifestyle indexes into account, are warranted in the future.
eng
WCRF
AICR score
Low-risk lifestyle index
Colorectal cancer
PREDIMED
Lifestyle patterns
Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study
research article