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00925njm 22002777a 4500 dc Barrubes, Laura author Babio, Nancy author Hernandez-Alonso, Pablo author Toledo, Estefanía author Ramirez Sabio, Judith B author Estruch, Ramon author Ros, Emilio author Fito, Montserrat author Alonso-Gomez, Angel M author Fiol Sala, Miquel author Lapetra, Jose author Serra-Majem, Lluis author Pinto, Xavier author Ruiz-Canela, Miguel author Corella, Dolores author Castaner, Olga author Macias-Gonzalez, Manuel author Salas-Salvado, Jordi author 2020-04 Limited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other global lifestyle indices, and none in aged populations at high cardiovascular risk. We aimed to assess the association between CRC incidence and adherence to two emerging lifestyles indices (2018 WCRF/AICR score and another low-risk lifestyle (LRL) score comprising smoking status, alcohol consumption, physical activity, diet, and body mass index) in the Spanish PREvencion con DIeta MEDiterranea (PREDIMED) cohort. We studied 7216 elderly men and women at high cardiovascular risk. The 2018 WCRF/AICR and LRL scores were calculated. Multivariable Cox proportional regression models were fitted to estimate the HRs (hazard ratios) and 95% confidence intervals (CIs) for incident CRC events. During a median interquartile range (IQR) follow-up of 6.0 (4.4-7.3) years, 97 CRC events were considered. A significant linear association was observed between each 1-point increment in the WCRF/AICR score (score range from 0 to 7) and CRC risk (HR (95% CI) = 0.79 (0.63-0.99)). Similarly, each 1-point increment in the LRL score (score range from 0 to 5) was associated with a 22% reduction in CRC risk (0.78 (0.64-0.96)). Adhering to emergent lifestyle scores might substantially reduce CRC incidence in elderly individuals. Further longitudinal studies, which take different lifestyle indexes into account, are warranted in the future. Barrubes L, Babio N, Hernandez-Alonso P, Toledo E, Ramirez Sabio JB, Estruch R, et al. Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study. J Clin Med. 2020 Apr;9(4):1215. 10.3390/jcm9041215 2077-0383 Journal of Clinical Medicine http://hdl.handle.net/20.500.13003/11154 32340309 L2004225718 2-s2.0-85110285108 https://hdl.handle.net/20.500.12105/22957 531821000322 WCRF AICR score Low-risk lifestyle index Colorectal cancer PREDIMED Lifestyle patterns Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study