2026-05-17T01:18:34Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/229472024-11-28T20:34:29Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Monserrat-Mesquida, Margalida author Quetglas-Llabrés, Magdalena author Capó Fiol, Xavier author Bouzas, Cristina author Mateos, David author Pons, Antoni author Tur, Josep A author Soldevila Verdeguer, Carla author 2020-03 Metabolic syndrome (MetS) is associated with increased risk of developing diabetes and cardiovascular diseases. MetS is also characterized by an increase of oxidative stress which contributes to impaired inflammation, vascular function, and atherosclerosis. The aim was to assess the oxidative stress and inflammatory markers in plasma and PBMCs in adults with or without MetS. Antioxidant and inflammatory parameters were measured in peripheral blood mononuclear cells (PBMCs) of 80 men and 80 women over 55 to 80-years-old residing in the Balearic Islands without previously documented cardiovascular disease. Circulating leukocytes, neutrophils, lymphocytes, basophils, and monocytes were higher in MetS subjects with respect to those without MetS. Plasma levels of malondialdehyde, tumor necrosis factor alpha (TNF alpha), and interleukin 6 (IL-6) levels were higher in MetS subjects in both genders, but the superoxide dismutase activity was lower. The myeloperoxidase plasma activity was higher in the MetS male subjects. Higher activities and protein levels of catalase and glutathione reductase in PBMCs were observed in MetS subjects in both genders. Obtained data show that MetS is associated with oxidative stress and a proinflammatory state and with high antioxidant defenses in PBMCs probably derived from a pre-activation state of immune cells. Monserrat-Mesquida M, Quetglas-Llabres M, Capo X, Bouzas C, Mateos D, Pons A, et al. Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State. Antioxidants. 2020 Mar;9(3):236. 10.3390/antiox9030236 2076-3921 Antioxidants http://hdl.handle.net/20.500.13003/11520 32178436 2-s2.0-85081621235 https://hdl.handle.net/20.500.12105/22947 524490700041 Metabolic syndrome Oxidative stress Cytokine Inflammation PBMCs Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State