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oai:repisalud.isciii.es:20.500.12105/229412024-11-29T05:18:47Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Salehi, Bahare author Azzini, Elena author Zucca, Paolo author Varoni, Elena Maria author Kumar, Nanjangud V. Anil author Dini, Luciana author Panzarini, Elisa author Rajkovic, Jovana author Fokou, Patrick Valere Tsouh author Peluso, Ilaria author Mishra, Abhay Prakash author Nigam, Manisha author El Rayess, Youssef author El Beyrouthy, Marc author Setzer, William N author Polito, Letizia author Iriti, Marcello author Soldevila Verdeguer, Carla author Quetglas-Llabres, Maria Magdalena author Martorell, Miquel author Martins, Natalia author Sharifi-Rad, Mehdi author Estevinho, Leticia M author Sharifi-Rad, Javad author 2020-02 Plants and their corresponding botanical preparations have been used for centuries due to their remarkable potential in both the treatment and prevention of oxidative stress-related disorders. Aging and aging-related diseases, like cardiovascular disease, cancer, diabetes, and neurodegenerative disorders, which have increased exponentially, are intrinsically related with redox imbalance and oxidative stress. Hundreds of biologically active constituents are present in each whole plant matrix, providing promissory bioactive effects for human beings. Indeed, the worldwide population has devoted increased attention and preference for the use of medicinal plants for healthy aging and longevity promotion. In fact, plant-derived bioactives present a broad spectrum of biological effects, and their antioxidant, anti-inflammatory, and, more recently, anti-aging effects, are considered to be a hot topic among the medical and scientific communities. Nonetheless, despite the numerous biological effects, it should not be forgotten that some bioactive molecules are prone to oxidation and can even exert pro-oxidant effects. In this sense, the objective of the present review is to provide a detailed overview of plant-derived bioactives in age-related disorders. Specifically, the role of phytochemicals as antioxidants and pro-oxidant agents is carefully addressed, as is their therapeutic relevance in longevity, aging-related disorders, and healthy-aging promotion. Finally, an eye-opening look into the overall evidence of plant compounds related to longevity is presented. Salehi B, Azzini E, Zucca P, Varoni EM, Kumar NVA, Dini L, et al. Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion. Appl Sci-Basel. 2020 Feb;10(3):947. 10.3390/app10030947 2076-3417 Applied Sciences-Basel http://hdl.handle.net/20.500.13003/11864 2-s2.0-85081559790 https://hdl.handle.net/20.500.12105/22941 525305900218 Medicinal plants Bioactive molecules Phenolic compounds Oxidative stress Antioxidants Chronic disorders Health maintenance Longevity Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion