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oai:repisalud.isciii.es:20.500.12105/229362024-11-28T23:39:00Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Sanchis, Pilar author Molina, Marilisa author Berga, Francisco author Muñoz, Elena author Fortuny Marques, Regina author Costa-Bauza, Antonia author Grases, Felix author Buades-Fuster, Juan Manuel 2024-09-13T09:13:36Z 2024-09-13T09:13:36Z 2020-01 Sanchis P, Molina Guasch M, Berga Montaner F, Muñoz E, Fortuny Marques R, Costa-Bauza A, et al. A Pilot Randomized Crossover Trial Assessing the Safety and Short-Term Effects of Walnut Consumption by Patients with Chronic Kidney Disease. Nutrients. 2020 Jan;12(1):63. 10.3390/nu12010063 2072-6643 Nutrients http://hdl.handle.net/20.500.13003/12409 31881702 L2003420876 2-s2.0-85077257172 https://hdl.handle.net/20.500.12105/22936 516825500063 The aim of this study of patients with chronic kidney disease (CKD) is to assess the safety of daily consumption of walnuts on the physiological levels of phosphorous, potassium, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23), and to assess the short-term benefits of this intervention on risk factors associated with cardiovascular events. This led us to perform a prospective, randomized, crossover, pilot clinical trial examined 13 patients with CKD. Subjects were randomly assigned to a diet of 30 g of walnuts per day or the control diet. After 30 days, each group was given a 30-day washout period, and then switched to the alternate diet for 30 days. Urinary and serum levels of phosphorous and potassium, multiple vascular risk factors, and urinary inositol phosphates (InsPs) were measured at baseline and at the end of the intervention period. Our results showed that the walnut dietary supplement led to reduced blood pressure, LDL cholesterol, and albumin excretion, but had no effect on the physiological levels of phosphorous, potassium, PTH, and FGF23. This is the first report to show that daily consumption of walnuts by patients with CKD does not alter their physiological levels of phosphorous, potassium, PTH, and FGF23 when included in a sodium-, protein-, phosphate-, and potassium-controlled diet, and it could be an effective strategy for reducing cardiovascular risk in patients with CKD. eng Walnuts Kidney disease Phytate Dietary intervention Phosphorous A Pilot Randomized Crossover Trial Assessing the Safety and Short-Term Effects of Walnut Consumption by Patients with Chronic Kidney Disease research article