2026-07-21T14:00:53Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/229262024-09-13T09:13:32Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Suntar, Ipek author Soldevila Verdeguer, Carla author Belwal, Tarun author Silva, Ana Sanches author Vacca, Rosa Anna author Tewari, Devesh author Sobarzo-Sanchez, Eduardo author Nabavi, Seyed Fazel author Shirooie, Samira author Dehpour, Ahmad Reza author Xu, Suowen author Yousefi, Bahman author Majidinia, Maryam author Daglia, Maria author D'Antona, Giuseppe author Nabavi, Seyed Mohammad author 2020-05 Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a transcriptional coactivator that binds to a diverse range of transcription factors. PPAR gamma coactivator 1 (PGC-1) coactivators possess an extensive range of biological effects in different tissues, and play a key part in the regulation of the oxidative metabolism, consequently modulating the production of reactive oxygen species, autophagy, and mitochondrial biogenesis. Owing to these findings, a large body of studies, aiming to establish the role of PGC-1 in the neuromuscular system, has shown that PGC-1 could be a promising target for therapies targeting neuromuscular diseases. Among these, some evidence has shown that various signaling pathways linked to PGC-1 alpha are deregulated in muscular dystrophy, leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species (ROS) production. In the light of these results, any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular dystrophies. PGC-1 alpha is influenced by different patho-physiological/pharmacological stimuli. Natural products have been reported to display modulatory effects on PPAR gamma activation with fewer side effects in comparison to synthetic drugs. Taken together, this review summarizes the current knowledge on Duchenne muscular dystrophy, focusing on the potential effects of natural compounds, acting as regulators of PGC-1 alpha. Suntar I, Sureda Gomila A, Belwal T, Sanches Silva A, Vacca RA, Tewari D, et al. Natural products, PGC-1 alpha, and Duchenne muscular dystrophy. Acta Pharm Sin B. 2020 May;10(5):734-45. Epub 2020 Jan 8. 10.1016/j.apsb.2020.01.001 2211-3843 2211-3835 Acta Pharmaceutica Sinica B http://hdl.handle.net/20.500.13003/17243 32528825 L2004992484 2-s2.0-85079816616 https://hdl.handle.net/20.500.12105/22926 538982700002 Muscular dystrophy Natural product Peroxisome proliferatoractivated receptor gamma coactivator 1 alpha; PPAR gamma activation Reactive oxygen species Mitochondrial oxidative phosphorylation Natural products, PGC-1 alpha, and Duchenne muscular dystrophy