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Repisalud author Garcia Castillo, Elena author Alonso Perez, Tamara author Ancochea, Julio author Pastor Sanz, Maria Teresa author Almagro, Pere author Martinez-Camblor, Pablo author Miravitlles, Marc author Rodriguez-Carballeira, Monica author Navarro, Annie author Lamprecht, Bernd author Ramirez-Garcia Luna, Ana S author Kaiser, Bernhard author Alfageme, Inmaculada author Casanova, Ciro author Esteban, Cristobal author Soler-Cataluna, Juan J author de-Torres, Juan P author Celli, Bartolome R author Marin, Jose M author ter Riet, Gerben author Sobradillo, Patricia author Lange, Peter author Garcia-Aymerich, Judith author Anto, Josep M author Turner, Alice M author Han, MeiLan K author Langhammer, Arnulf author Vikjord, Sigrid Anna Aalberg author Sternberg, Alice author Leivseth, Linda author Bakke, Per author Johannessen, Ane author Oga, Toru author García-Cosío, Borja author Echazarreta, Andres author Roche, Nicolas author Burgel, Pierre-Regis author Sin, Don D author Puhan, Milo A author Lopez-Campos, Jose Luis author Carrasco, Laura author Soriano, Joan B author 3CIA Collaboration 2024-09-13T09:13:28Z 2024-09-13T09:13:28Z 2020-10-01 Garcia Castillo E, Alonso Perez T, Ancochea J, Pastor Sanz MT, Almagro P, Martinez-Camblor P, et al. Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2015 and GOLD 2019 staging: a pooled analysis of individual patient data. ERJ Open Res. 2020 Oct 01;6(4):00253-2020. 10.1183/23120541.00253-2020 2312-0541 ERJ Open Research http://hdl.handle.net/20.500.13003/17236 33263033 L2005601612 2-s2.0-85114072682 https://hdl.handle.net/20.500.12105/22910 603682700045 In 2019, The Global Initiative for Chronic Obstructive Lung Disease (GOLD) modified the grading system for patients with COPD, creating 16 subgroups (1A-4D). As part of the COPD Cohorts Collaborative International Assessment (3CIA) initiative, we aim to compare the mortality prediction of the 2015 and 2019 COPD GOLD staging systems. We studied 17 139 COPD patients from the 3CIA study, selecting those with complete data. Patients were classified by the 2015 and 2019 GOLD ABCD systems, and we compared the predictive ability for 5-year mortality of both classifications. In total, 17139 patients with COPD were enrolled in 22 cohorts from 11 countries between 2003 and 2017; 8823 of them had complete data and were analysed. Mean +/- SD age was 63.9 +/- 9.8 years and 62.9% were male. GOLD 2019 classified the patients in milder degrees of COPD. For both classifications, group D had higher mortality. 5-year mortality did not differ between groups B and C in GOLD 2015; in GOLD 2019, mortality was greater for group B than C. Patients classified as group A and B had better sensitivity and positive predictive value with the GOLD 2019 classification than GOLD 2015. GOLD 2015 had better sensitivity for group C and D than GOLD 2019. The area under the curve values for 5-year mortality were only 0.67 (95% CI 0.66-0.68) for GOLD 2015 and 0.65 (95% CI 0.63-0.66) for GOLD 2019. The new GOLD 2019 classification does not predict mortality better than the previous GOLD 2015 system. eng Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2015 and GOLD 2019 staging: a pooled analysis of individual patient data research article