2026-04-29T04:52:16Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/228992024-11-29T04:14:10Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Gonzalez-Freire, Marta author Diaz-Ruiz, Alberto author Hauser, David author Martinez-Romero, Jorge author Ferrucci, Luigi author Bernier, Michel author de Cabo, Rafael author 2020-05 Aging is a modifiable risk factor for most chronic diseases and an inevitable process in humans. The development of pharmacological interventions aimed at delaying or preventing the onset of chronic conditions and other age-related diseases has been at the forefront of the aging field. Preclinical findings have demonstrated that species, sex and strain confer significant heterogeneity on reaching the desired health- and lifespan-promoting pharmacological responses in model organisms. Translating the safety and efficacy of these interventions to humans and the lack of reliable biomarkers that serve as predictors of health outcomes remain a challenge. Here, we will survey current pharmacological interventions that promote lifespan extension and/or increased healthspan in animals and humans, and review the various anti-aging interventions selected for inclusion in the NIA's Interventions Testing Program as well as the ClinicalTrials.gov database that target aging or age-related diseases in humans. Gonzalez-Freire M, Diaz-Ruiz A, Hauser D, Martinez-Romero J, Ferrucci L, Bernier Ml, et al. The road ahead for health and lifespan interventions. Ageing Res Rev. 2020 May;59:101037. Epub 2020 Feb 25. 1568-1637 http://hdl.handle.net/20.500.13003/17245 https://hdl.handle.net/20.500.12105/22899 32109604 10.1016/j.arr.2020.101037 1872-9649 Ageing Research Reviews 2-s2.0-85080096327 525863700004 L2005097568 Lifespan Healthspan Aging anti-aging Longevity Frailty Translation The road ahead for health and lifespan interventions