2026-05-22T07:43:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/228952024-11-29T07:54:35Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Vallejo-Diez, Sara
author
Martin-Fernandez, Jose Maria
author
Sanchez-Gilabert, Almudena
author
Fleischer, Aarne
author
Gayà, Antoni
author
Castresana, Monica
author
Bachiller, Daniel
2024-09-13T09:13:25Z
2024-09-13T09:13:25Z
2020-08
Vallejo-Diez S, Martin-Fernandez JM, Sanchez-Gilabert A, Fleischer A, Gaya A, Castresana M, et al. Generation of a human iPSC line (IMEDEAi008-A) derived from natural homozygous CCR5-Delta 32 PBMCs enriched in the pro-erythroblast population [editorial]. Stem Cell Research. 2020 Aug;47:101918. Epub 2020 Jul 17.
10.1016/j.scr.2020.101918
1876-7753
1873-5061
Stem Cell Research
http://hdl.handle.net/20.500.13003/17240
32702648
L2007107187
2-s2.0-85088149823
https://hdl.handle.net/20.500.12105/22895
566517800012
A 32 base pair deletion in the C-C chemokine receptor type gene (CCR5-Delta 32), the main Human Immunodeficiency Virus (HIV) co-receptor results in a non-functional protein. Individuals homozygous for the CCR5-Delta 32 mutation are resistant to HIV infection. Here we report the generation, from pro-erythroblast enriched Peripheral Blood Mononuclear Cells (PBMCs) from a naturally occurring CCR5-Delta 32/Delta 32 individual, of the fully characterized iPSC line IMEDEAi008-A. The new line has normal karyotype, carry the Delta 32 mutation in homozygosity, is free of plasmid integrations, express high levels of pluripotency markers and can differentiate into all three germ layers.
eng
Generation of a human iPSC line (IMEDEAi008-A) derived from natural homozygous CCR5-Delta 32 PBMCs enriched in the pro-erythroblast population
editorial