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oai:repisalud.isciii.es:20.500.12105/228932024-11-28T19:52:28Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Torrens-Mas, Margalida author Pons, Daniel-Gabriel author Sastre-Serra, Jorge author Oliver, Jordi author Roca, Pilar author 2020-04 Compared to other organs, the brain is especially exposed to oxidative stress. In general, brains from young females tend to present lower oxidative damage in comparison to their male counterparts. This has been attributed to higher antioxidant defenses and a better mitochondrial function in females, which has been linked to neuroprotection in this group. However, these differences usually disappear with aging, and the incidence of brain pathologies increases in aged females. Sexual hormones, which suffer a decrease with normal aging, have been proposed as the key factors involved in these gender differences. Here, we provide an overview of redox status and mitochondrial function regulation by sexual hormones and their influence in normal brain aging. Furthermore, we discuss how sexual hormones, as well as phytoestrogens, may play an important role in the development and progression of several brain pathologies, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, stroke or brain cancer. Torrens-Mas M, Pons D, Sastre-Serra J, Oliver Oliver , Roca P. Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications. Redox Biol. 2020 Apr;31:101505. Epub 2020 Mar 14. 10.1016/j.redox.2020.101505 2213-2317 Redox Biology http://hdl.handle.net/20.500.13003/17247 32201220 L2005279585 2-s2.0-85082821131 https://hdl.handle.net/20.500.12105/22893 533802200006 Sex hormones Brain Redox homeostasis Mitochondrial function Aging Sex differences Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications