2026-05-22T00:28:52Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/228902024-11-28T20:48:46Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Lefaki, Maria
author
Papaevgeniou, Nikoletta
author
Tur, Josep A
author
Vorgias, Constantinos E
author
Sykiotis, Gerasimos P
author
Chondrogianni, Niki
2024-09-13T09:11:54Z
2024-09-13T09:11:54Z
2020-01
Lefaki M, Papaevgeniou N, Tur JA, Vorgias CE, Sykiotis GP, Chondrogianni N. The dietary triterpenoid 18 alpha-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway. Redox Biol. 2020 Jan;28:101317.
10.1016/j.redox.2019.101317
2213-2317
Redox Biology
https://hdl.handle.net/20.500.13003/19854
31505326
L2002834091
2-s2.0-85071869131
https://hdl.handle.net/20.500.12105/22890
501490700063
18 alpha-Glycyrrhetinic acid (18 alpha-GA) is a bioactive triterpenoid that has been shown to activate the nuclear factor (erythroid-derived-2)-like 2 (Nrf2), the main transcription factor that orchestrates the cellular antioxidant response, in both cellular and organismal context. Although various beneficial properties of 18 alpha-GA have been revealed, including its anti-oxidation and anti-aging activity, its possible protective effect against DNA damage has never been addressed. In this study, we investigated the potential beneficial properties of 18 alpha-GA against DNA damage induced by mitomycin C (MMC) treatment. Using human primary fibroblasts exposed to MMC following pre-treatment with 18 alpha-GA, we reveal an Nrf2-mediated protective effect against MMC-induced cell death that depends on extracellular signal-regulated kinase (ERK) signaling. In total, our results reveal an additional beneficial effect of the Nrf2 activator 18 alpha-GA, suggesting that this important phytochemical compound is a potential candidate in preventive and/or therapeutic schemes against conditions (such as aging) or diseases that are characterized by both oxidative stress and DNA damage.
eng
18 alpha-Glycyrrhetinic acid
Nrf2
DNA damage
Mitomycin C
ERK pathway
Phytochemicals
The dietary triterpenoid 18 alpha-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway
research article