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oai:repisalud.isciii.es:20.500.12105/228902024-11-28T20:48:46Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Lefaki, Maria author Papaevgeniou, Nikoletta author Tur, Josep A author Vorgias, Constantinos E author Sykiotis, Gerasimos P author Chondrogianni, Niki author 2020-01 18 alpha-Glycyrrhetinic acid (18 alpha-GA) is a bioactive triterpenoid that has been shown to activate the nuclear factor (erythroid-derived-2)-like 2 (Nrf2), the main transcription factor that orchestrates the cellular antioxidant response, in both cellular and organismal context. Although various beneficial properties of 18 alpha-GA have been revealed, including its anti-oxidation and anti-aging activity, its possible protective effect against DNA damage has never been addressed. In this study, we investigated the potential beneficial properties of 18 alpha-GA against DNA damage induced by mitomycin C (MMC) treatment. Using human primary fibroblasts exposed to MMC following pre-treatment with 18 alpha-GA, we reveal an Nrf2-mediated protective effect against MMC-induced cell death that depends on extracellular signal-regulated kinase (ERK) signaling. In total, our results reveal an additional beneficial effect of the Nrf2 activator 18 alpha-GA, suggesting that this important phytochemical compound is a potential candidate in preventive and/or therapeutic schemes against conditions (such as aging) or diseases that are characterized by both oxidative stress and DNA damage. Lefaki M, Papaevgeniou N, Tur JA, Vorgias CE, Sykiotis GP, Chondrogianni N. The dietary triterpenoid 18 alpha-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway. Redox Biol. 2020 Jan;28:101317. 10.1016/j.redox.2019.101317 2213-2317 Redox Biology https://hdl.handle.net/20.500.13003/19854 31505326 L2002834091 2-s2.0-85071869131 https://hdl.handle.net/20.500.12105/22890 501490700063 18 alpha-Glycyrrhetinic acid Nrf2 DNA damage Mitomycin C ERK pathway Phytochemicals The dietary triterpenoid 18 alpha-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway