2026-06-14T03:29:48Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/228802024-11-28T19:38:44Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Kritikos, Vicky
author
Price, David
author
Papi, Alberto
author
Infantino, Antonio
author
Stallberg, Bjorn
author
Ryan, Dermot
author
Lavorini, Federico
author
Chrystyn, Henry
author
Haughney, John
author
Lisspers, Karin
author
Gruffydd-Jones, Kevin
author
Rodriguez, Miguel Roman
author
Henrichsen, Svein Hoegh
author
van der Molen, Thys
author
Carter, Victoria
author
Bosnic-Anticevich, Sinthia
2024-09-13T09:11:49Z
2024-09-13T09:11:49Z
2020
Kritikos V, Price D, Papi A, Infantino A, Stallberg B, Ryan D, et al. The Burden of Self-Reported Rhinitis and Associated Risk for Exacerbations with Moderate-Severe Asthma in Primary Care Patients. J ASTHMA ALLERGY. 2020;13:415-28.
10.2147/JAA.S266204
1178-6965
Journal of Asthma and Allergy
http://hdl.handle.net/20.500.13003/17133
33116650
L2005171176
2-s2.0-85092149851
https://hdl.handle.net/20.500.12105/22880
582616100001
Purpose: There is a dearth of research regarding the prevalence and nature of patient-reported rhinitis and its relationship with risk of asthma exacerbations. The aim of this study was to (i) determine the prevalence, severity and treatment of self-reported rhinitis symptoms among adults aged >= 18 years with asthma treated at Global Initiative for Asthma (GINA) Step 3 and above and (ii) compare the demographics, clinical characteristics, medication use, side-effects and healthcare practitioner review between patients who report rhinitis symptoms and those who do not and (iii) determine whether patient-reported rhinitis is associated with risk of asthma exacerbations in the total patient sample. Patients and Methods: This analysis used data from the iHARP (Initiative Helping Asthma in Real-life Patients) asthma review service - a cross-sectional observational study (2011 and 2014) in seven countries that captured data on patient demographics, rhinitis symptoms, asthma symptoms, indicators of exacerbations, medication use, oropharyngeal effects and side-effects, using practitioner- and patient-reported questionnaires. Comparisons between patients with and without rhinitis were tested. Univariate logistic regression was used to identify variables associated with risk of exacerbations for entry into multivariable logistic regression. Results: This report contains data from 4274 patients: 67.4% (2881/4274) reported rhinitis symptoms and of which 65.7% (1894/2881) had not received a doctor diagnosis; 36.5% (1052/2881) had moderate-severe rhinitis, 12.4% (358/2881) had used intranasal corticosteroids and 19.8% (569/2881) oral antihistamines. Patients with coexisting moderate-severe rhinitis were more likely to have GINA-defined uncontrolled asthma than those with mild rhinitis or no rhinitis. Moderate-severe rhinitis was associated with 40% increased risk of asthma exacerbations (OR=1.40, 95% CI: 1.02-1.90). Conclusion: This study identified a major gap in the diagnosis and management of rhinitis in a cohort of people with asthma treated at GINA Step 3 and above who are managed in general practice. It highlights the need for practitioners to identify, evaluate and optimally treat rhinitis in adults with asthma, which is a significant factor associated with exacerbation risk.
eng
Asthma symptom control
Comorbidities
Oral steroids
Preventer
Reliever
Side-effects
The Burden of Self-Reported Rhinitis and Associated Risk for Exacerbations with Moderate-Severe Asthma in Primary Care Patients
research article