2026-05-17T05:52:33Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/228572024-11-29T01:09:25Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Torrecilla, Carlos author Fernandez-Concha, Jaime author Cansino, Jose R author Mainez, Juan A author Amon, Jose H author Costas, Simbad author Angerri, Oriol author Emiliani, Esteban author Arrabal Martin, Miguel A author Arrabal Polo, Miguel A author Garcia, Ana author Reina, Manuel C author Sanchez, Juan F author Budia, Alberto author Perez-Fentes, Daniel author Grases, Felix author Costa-Bauza, Antonia author Cune, Jordi author 2020-06-05 Background: Encrustation of ureteral double J stents is a common complication that may affect its removal. The aim of the proposed study is to evaluate the efficacy and safety of a new oral composition to prevent double J stent encrustation in indwelling times up to 8 weeks. Methods: A double-blinded, multicenter, placebo-controlled trial was conducted with 105 patients with indwelling double J stents enrolled across 9 public hospitals in Spain. The patients were randomly assigned (1:1) into intervention (53 patients) or placebo (52 patients) groups for 3 to 8 weeks and both groups self-monitored daily their morning urine pH levels. The primary outcome of analysis was the degree of stent ends encrustation, defined by a 4-point score (0 - none; 3 - global encrustation) using macroscopic and electron microscopy analysis of crystals, after 3 to 8-w indwelling period. Score was exponentially transformed according to calcium levels. Secondary endpoints included urine pH decrease, stent removal, and incidence of adverse events. Results: The intervention group benefits from a lower global encrustation rate of stent ends than placebo group (1% vs 8.2%; p < 0.018). Mean encrustation score was 85.12 (274.5) in the placebo group and 18.91 (102.27) in the intervention group (p < 0.025). Considering the secondary end points, treated patients reported greater urine pH decreases (p = 0.002). No differences in the incidence of adverse events were identified between the groups. Conclusions: Our data suggest that the use of this new oral composition is beneficial in the context of ureteral double J indwelling by decreasing mean, as well as global encrustation. Torrecilla C, Fernandez-Concha J, Cansino JR, Mainez JA, Amon JH, Costas S, et al. Reduction of ureteral stent encrustation by modulating the urine pH and inhibiting the crystal film with a new oral composition: a multicenter, placebo controlled, double blind, randomized clinical trial. BMC Urol. 2020 Jun 05;20(1):65. 10.1186/s12894-020-00633-2 1471-2490 BMC Urology http://hdl.handle.net/20.500.13003/10365 32503502 L631999404 2-s2.0-85086008487 https://hdl.handle.net/20.500.12105/22857 540247800001 Double J stent Encrustation Nutraceutical L-methionine Phytin pH Reduction of ureteral stent encrustation by modulating the urine pH and inhibiting the crystal film with a new oral composition: a multicenter, placebo controlled, double blind, randomized clinical trial