2026-04-29T04:58:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/228502024-11-28T18:25:54Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16962col_20.500.12105_16967
Repisalud
author
Bullon-Vela, Vanessa
author
Abete, Itziar
author
Angeles Zulet, M
author
Tur, Josep A
author
Pinto, Xavier
author
Corbella, Emili
author
Martinez-Gonzalez, Miguel A
author
Corella, Dolores
author
Macias-Gonzalez, Manuel
author
Tinahones, Francisco
author
Fito, Montserrat
author
Estruch, Ramon
author
Ros, Emilio
author
Salas-Salvado, Jordi
author
Daimiel, Lidia
author
Alfredo Martinez, J
2024-09-13T09:11:41Z
2024-09-13T09:11:41Z
2020
Bullon-Vela V, Abete I, Zulet MA, Tur JA, Pinto X, Corbella E, et al. Risk factors differentially associated with non-alcoholic fatty liver disease in males and females with metabolic syndrome. Rev Esp Enferm Dig. 2020;112(2):94-100.
1130-0108
https://hdl.handle.net/20.500.13003/19799
https://hdl.handle.net/20.500.12105/22850
31880161
10.17235/reed.2019.6031/2018
2340-4167
Revista Espanola de Enfermedades Digestivas
2-s2.0-85079320288
512983800004
L2005670795
Background and aims: non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in western countries.This study aimed to investigate putative risk factors differentially related with NAFLD in obese males and females diagnosed with metabolic syndrome (MetS), stratified using the non-invasive hepatic steatosis index (HSI). Methods: a cross-sectional analysis of the PREDIMED Plus study was performed of 278 participants with MetS (141 males and 137 females) of the Navarra-Nutrition node. Subjects were categorized by HSI tertiles and gender. Baseline clinical, biochemical variants and adherence to a Mediterranean diet and physical activity were evaluated. Results: multivariate analyses showed that females had 4.54 more units of HSI (95% CI: 3.41 to 5.68) than males. Both sexes showed increased levels of triglycerides,TG/HDL cholesterol ratio and triglyceride glucose index across the HSI tertiles. Physical activity exhibited a negative statistical association with HSI (males: r = -0.19, p = 0.025; females: r = -0.18, p = 0.031). The amount of visceral fat showed a positive association with HSI in both sexes (males: r = 0.64, p < 0.001; females: r = 0.46, p < 0.001). Adherence to the Mediterranean diet was lower in those subjects with higher HSI values (males: r = -0.18, p = 0.032; females r= -0.19, p = 0.027). Conclusion: females had a poor liver status, suggesting gender differences related to NAFLD. Adherence to a Mediterranean diet and physical activity were associated with beneficial effects on cardiovascular disease features.Thus, reducing the risk of hepatic steatosis in subjects with MetS and obesity.
eng
Non-alcoholic fatty liver disease
Abdominal obesity
Metabolic syndrome
Visceral adipose tissue
Sex
Risk factors differentially associated with non-alcoholic fatty liver disease in males and females with metabolic syndrome
research article