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oai:repisalud.isciii.es:20.500.12105/228442024-11-29T01:41:30Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Rahmati, Maryam author Frank, Matthias Johannes author Walter, Sebastian Martin author Cabrer Monjo, Marta author Satue, Maria author Reseland, Janne Elin author Lyngstadaas, Stale Petter author Haugen, Havard Jostein author 2020-08-17 Over the past few years, surface modification of implant surfaces has gained substantial attention as a promising solution to avoid the failure of biomaterials after implantation. Although researchers suggest several strategies for surface functionalization of titanium-based implants, only a few studies have compared the osteoimmunomodulatory effects of ionic nanostructures and biofunctionalization in the same biological model. Enamel matrix derivate (EMD) and strontium are both known for their positive influences on bone cell responses. In this study, we functionalized the titanium-zirconium implant surface with EMD and strontium using an electrochemical cathodic polarization method. Afterward, we evaluated the osteoimmunomodulatory effects of EMD or strontium coated titanium-zirconium implants in the tibia of eight Gray Bastard Chinchilla rabbits. We performed 2 and 3D micro-CT, wound fluid, histologic, and histomorphometric analyses on bone tissues after 4- and 8-weeks of implantation. Although the results could indicate some differences between groups regarding the bone quality, there was no difference in bone amount or volume. EMD stimulated higher ALP activity and lower cytotoxicity in wound fluid, as well as a lower expression of inflammatory markers after 8 weeks indicating its osteoimmunomodulatory effects after implantation. Overall, the results suggested that ionic nanostructure modification and biofunctionalization might be useful in regulating the immune responses to implants. Rahmati M, Frank MJ, Walter SM, Cabrer Monjo M, Satue M, Reseland JE, et al. Osteoimmunomodulatory Effects of Enamel Matrix Derivate and Strontium Coating Layers: A Short- and Long-Term In Vivo Study. ACS Appl Bio Mater. 2020 Aug 17;3(8):5169-81. Epub 2020 Jul 23. 10.1021/acsabm.0c00608 2576-6422 Acs Applied Bio Materials http://hdl.handle.net/20.500.13003/9742 32954227 L637590862 2-s2.0-85090932101 https://hdl.handle.net/20.500.12105/22844 604598800044 Bioactive coating Enamel matrix derivate Strontium Titanium-zirconium Biointerface Osteoimmunomodulation Osteoimmunomodulatory Effects of Enamel Matrix Derivate and Strontium Coating Layers: A Short- and Long-Term In Vivo Study