2026-04-29T19:06:30Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/228352024-09-10T13:10:43Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Andres, Pilar author Vico, Helena author Yáñez, Aina M author Siquier, Antónia author Amer Ferrer, Guillermo author 2019 Introduction: In the present study, we use the item-specific deficit approach (ISDA), a method for characterizing memory deficits in list-learning, to portray the memory deficits in amnestic mild cognitive impairment (aMCI).Methods: We applied the ISDA to compare memory performance of patients with aMCI and healthy controls in encoding, consolidation, and retrieval using the Free and Cued Selective Reminding Test.Results: The results revealed clear differences in recall performance between patients with aMCI and controls. When analyzing the ISDA deficit indices, the results revealed a prominent encoding deficit, followed by a consolidating deficit. A greater sensitivity for the encoding index confirmed that a difficulty with encoding information plays a major role in explaining the episodic memory deficits experienced by patients with aMCI.Discussion: The present study applying the ISDA reveals great sensitivity and specificity of the encoding deficit index when identifying aMCI. As aMCI constitutes a risk factor to develop Alzheimer's disease, the current findings also confirm the need to concentrate on encoding deficits as an early diagnostic sign of cognitive decline. Andres P, Vico H, Yañez A, Siquier A, Amer Ferrer G. Quantifying memory deficits in amnestic mild cognitive impairment.. Alzheimers Dement (Amst). 2019;11:108-114. 10.1016/j.dadm.2018.12.002 2352-8729 Alzheimer'S & Dementia (Amsterdam, Netherlands) http://hdl.handle.net/20.500.13003/17420 30723774 L2001489486 2-s2.0-85060273868 https://hdl.handle.net/20.500.12105/22835 Encoding deficit Episodic memory ISDA method Neuropsychology aMCI Quantifying memory deficits in amnestic mild cognitive impairment.