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oai:repisalud.isciii.es:20.500.12105/228182024-11-29T02:36:34Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Bakuradze, Tamara author Tausend, Angelina author Galan, Jens author Groh, Isabel Anna Maria author Berry, David author Tur, Josep A author Marko, Doris author Richling, Elke author 2019-08-12 Oxidative cell damage has been linked to the pathogenesis of numerous diseases such as atherosclerosis, type 2 diabetes, and cancer. The consumption of foods rich in polyphenols (e.g. anthocyanins) has been shown to exert preventive effects against such diseases. We investigated the biological effects of anthocyanin-rich fruit juice in a 9-week, placebo-controlled intervention study with 57 healthy male volunteers. The study design encompassed an initial 1 week of wash-out, followed by 8 weeks of intervention period with anthocyanin-rich fruit juice or placebo. The anthocyanin-rich fruit juice demonstrated DNA-protective and antioxidant effects; however, the placebo beverage, rich in vitamin C, showed similar effects based on the tested biomarkers. A significant reduction in background and total DNA strand breaks was observed in both groups within 24 h as well as after 8 weeks of intervention. Only anthocyanin-rich fruit juice consumption provided a significant reduction in body fat and an increase in fat-free mass. The activity of superoxide dismutase (SOD) was significantly elevated after consumption of anthocyanin-rich fruit juice. Both groups showed decreased levels of LDL and total cholesterol (TC) within the first week of the intervention. Similar results in both groups could be explained by the relatively high vitamin C contents of both beverages (>500 mg/L), which may have masked the effects of anthocyanins and other antioxidants in the studied juice. Taken together, anthocyanin-rich fruit juice as well as the placebo drink, both of which had high vitamin C content, can improve DNA integrity and might influence lipid metabolism in humans. Bakuradze T, Tausend A, Galan J, Groh IAM, Berry D, Tur JA, et al. Antioxidative activity and health benefits of anthocyanin-rich fruit juice in healthy volunteers. Free Radic Res. 2019 Aug 12;53(Suppl 1):1045-55. Epub 2019 Jun 4. 10.1080/10715762.2019.1618851 1029-2470 1071-5762 Free Radical Research http://hdl.handle.net/20.500.13003/17542 31088176 L628058320 2-s2.0-85067015529 https://hdl.handle.net/20.500.12105/22818 600692100002 Anthocyanin-rich fruit juice Antioxidant Blood lipids Comet assay DNA strand breaks Antioxidative activity and health benefits of anthocyanin-rich fruit juice in healthy volunteers