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oai:repisalud.isciii.es:20.500.12105/227992024-11-28T19:33:09Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Fanjul, Francisco author Campins Rosselló, Antoni author Asensio Rodriguez, Javier author Samperiz, Gloria author Yáñez, Aina M author Romaguera, Dora author Fiol Sala, Miquel author Riera, Melchor author 2019-10-17 Background: Interatrial blocks are considered a new important risk factor for atrial fibrillation and cerebrovascular events. Their prevalence and clinical implications have been reported in general population and several subgroups of patients but no data from HIV-infected populations, with a non-negligible prevalence of atrial fibrillation, has been previously reported. Methods: We conducted a cross-sectional study in a previously enrolled cohort of randomly selected middle-aged HIV-infected patients who attended our hospital and were clinically stable. Patients underwent both a 12-lead rest electrocardiogram and clinical questionnaires while epidemiological, clinical and HIV-related variables were obtained from electronic medical records and interviews with the patients. Electrocardiograms were then analyzed and codified using a standardized form by two trained members of the research team who were blinded to clinical variables. Results: We obtained electrocardiograms from 204 patients with a mean age of 55.22 years, 39 patients (19.12%) presented an interatrial block, 9 (4.41%) advanced and 30 (14.71%) partial. Patients with interatrial block had a lower nadir lymphocyte CD4 count (124 vs 198 cells, p = 0.02) while advanced interatrial blocks were associated to older age (62.16 vs. 54.95 years, p = 0.046) and hypertension (77.8% vs. 32.3%, p = 0.009). We did not find differences regarding baseline CD4 lymphocyte count or CD4/CD8 lymphocyte ratio. Clinical variables and functional capacity among patients with or without interatrial block were similar. Conclusions: In a cohort of clinically stable HIV infected patients the prevalence of interatrial blocks, specially advanced, is high and associated to previously known factors (age, hypertension) and novel ones (nadir CD4 lymphocyte count). Fanjul F, Campins AA, Asensio J, Sampériz Abad G, Yañez AM, Romaguera D, et al. Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons. PLoS One. 2019 Oct 17;14(10):e0223777. 10.1371/journal.pone.0223777 1932-6203 PloS One http://hdl.handle.net/20.500.13003/14053 31622385 L2003423152 2-s2.0-85073589084 https://hdl.handle.net/20.500.12105/22799 532567300046 Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons