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00925njm 22002777a 4500 dc Hernaez, Alvaro author Soria-Florido, Maria Trinidad author Schroder, Helmut author Ros, Emilio author Pinto, Xavier author Estruch, Ramon author Salas-Salvado, Jordi author Corella, Dolores author Aros, Fernando author Serra-Majem, Lluis author Martinez-Gonzalez, Miguel Angel author Fiol Sala, Miquel author Lapetra, Jose author Elosua, Roberto author Lamuela-Raventos, Rosa María author Fito, Montserrat author 2019-06-27 Background: High-density lipoprotein (HDL) functionality and low-density lipoprotein (LDL) atherogenic traits can describe the role of both particles on cardiovascular diseases more accurately than HDL- or LDL-cholesterol levels. However, it is unclear how these lipoprotein properties are particularly affected by different cardiovascular risk factors. Objective: To determine which lipoprotein properties are associated with greater cardiovascular risk scores and each cardiovascular risk factor. Methods: In two cross-sectional baseline samples of PREDIMED trial volunteers, we assessed the associations of HDL functionality (N = 296) and LDL atherogenicity traits (N = 210) with: 1) the 10-year predicted coronary risk (according to the Framingham-REGICOR score), and 2) classical cardiovascular risk factors. Results Greater cardiovascular risk scores were associated with low cholesterol efflux values; oxidized, triglyceride-rich, small HDL particles; and small LDLs with low resistance against oxidation (P-trend<0.05, all). After adjusting for the rest of risk factors; 1) type-2 diabetic individuals presented smaller and more oxidized LDLs (P<0.026, all); 2) dyslipidemic participants had smaller HDLs with an impaired capacity to metabolize cholesterol (P<0.035, all); 3) high body mass index values were associated to lower HDL and LDL size and a lower HDL capacity to esterify cholesterol (P<0.037, all); 4) men presented a greater HDL oxidation and lower HDL vasodilatory capacity (P<0.046, all); and 5) greater ages were related to small, oxidized, cytotoxic LDL particles (P<0.037, all). Conclusions: Dysfunctional HDL and atherogenic LDL particles are present in high cardiovascular risk patients. Dyslipidemia and male sex are predominantly linked to HDL dysfunctionality, whilst diabetes and advanced age are associated with LDL atherogenicity. Hernaez A, Soria-Florido MT, Schroder H, Ros E, Pinto X, Estruch R, et al. Role of HDL function and LDL atherogenicity on cardiovascular risk: A comprehensive examination. PLoS One. 2019 Jun 27;14(6):e0218533. 10.1371/journal.pone.0218533 1932-6203 PloS One http://hdl.handle.net/20.500.13003/16275 31246976 L2002368447 2-s2.0-85068971562 https://hdl.handle.net/20.500.12105/22795 484911900027 Role of HDL function and LDL atherogenicity on cardiovascular risk: A comprehensive examination