2026-07-21T14:05:50Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/227862024-11-29T06:19:50Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc de Mendoza, Carmen author Piron, Maria author Gonzalez, Rocio author Jimenez, Ana author Caballero, Estrella author Roc, Lourdes author Benito, Rafael author Ramos, Jose Manuel author Soriano, Vicente author HTLV Spanish Study Group author 2019-02 Background. Although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late diagnoses. Methods. A nationwide HTLV-1 register was created in Spain in 1989. A total of 351 infected persons had been reported by the end of 2017. We examined all new HTLV-1 diagnoses during the last decade and compared their clinical presentation. Results. A total of 247 individuals with HTLV-1 infection had been reported in Spain since year 2008. The incidence has remained stable with 20-25 new diagnoses yearly. Women represented 62%. Only 12% were native Spaniards, most of whom were foreigners from Latin America (72.5%). Up to 57 (23%) individuals presented clinically with HTLV-1-associated conditions, including subacute myelopathy (n = 24; 42.1%), T-cell lymphoma (n = 19; 33.3%), or Strongyloides stercoralis infestation (n = 8; 14%). Human T-cell leukemia virus type 1 diagnosis had been made either at blood banks (n = 109; 44%) or at clinics (n = 138; 56%). It is interesting to note that Spaniards and especially Africans were overrepresented among patients presenting with HTLV-1-associated illnesses, suggesting that misdiagnosis and late presentation are more frequent in these populations compared to Latin Americans. Conclusions. Given that 23% of new HTLV-1 diagnoses in Spain are symptomatic, underdiagnosis must be common. Although screening in blood banks mostly identifies asymptomatic Latin American carriers, a disproportionately high number of Spaniards and Africans are unveiled too late, that is, they already suffer from classic HTLV-1 illnesses. De Mendoza C, Piron M, Gonzalez R, Jimenez A, Caballero E, Roc L, et al. Clinical Presentation of Individuals With Human T-Cell Leukemia Virus Type-1 Infection in Spain. Open Forum Infect Dis. 2019 Feb;6(2):ofz036. 10.1093/ofid/ofz036 2328-8957 Open Forum Infectious Diseases http://hdl.handle.net/20.500.13003/10108 30815504 L628039583 2-s2.0-85064261083 https://hdl.handle.net/20.500.12105/22786 461522500028 Adult T-cell leukemia Epidemiology HTLV-1 Myelopathy Screening Clinical Presentation of Individuals With Human T-Cell Leukemia Virus Type-1 Infection in Spain