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Repisalud author Lorente-Cebrian, Silvia author Herrera, Katya author Milagro, Fermin I author Sanchez, Juana author de la Garza, Ana Laura author Castro, Heriberto 2024-09-10T13:09:45Z 2024-09-10T13:09:45Z 2019-12 Lorente-Cebrian S, Herrera K, Milagro FI, Sánchez J, De la Garza AL, Castro H. miRNAs and Novel Food Compounds Related to the Browning Process. Int J Mol Sci. 2019 Dec;20(23):5998. http://hdl.handle.net/20.500.13003/12798 https://hdl.handle.net/20.500.12105/22770 31795191 10.3390/ijms20235998 1422-0067 International Journal of Molecular Sciences 2-s2.0-85075738586 504428300180 L2003259042 Obesity prevalence is rapidly increasing worldwide. With the discovery of brown adipose tissue (BAT) in adult humans, BAT activation has emerged as a potential strategy for increasing energy expenditure. Recently, the presence of a third type of fat, referred to as beige or brite (brown in white), has been recognized to be present in certain kinds of white adipose tissue (WAT) depots. It has been suggested that WAT can undergo the process of browning in response to stimuli that induce and enhance the expression of thermogenesis: a metabolic feature typically associated with BAT. MicroRNAs (miRNAs) are small transcriptional regulators that control gene expression in a variety of tissues, including WAT and BAT. Likewise, it was shown that several food compounds could influence miRNAs associated with browning, thus, potentially contributing to the management of excessive adipose tissue accumulation (obesity) through specific nutritional and dietetic approaches. Therefore, this has created significant excitement towards the development of a promising dietary strategy to promote browning/beiging in WAT to potentially contribute to combat the growing epidemic of obesity. For this reason, we summarize the current knowledge about miRNAs and food compounds that could be applied in promoting adipose browning, as well as the cellular mechanisms involved. eng miRNAs Browning BAT WAT Food compounds miRNAs and Novel Food Compounds Related to the Browning Process review article