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00925njm 22002777a 4500 dc Tresserra-Rimbau, Anna author Castro-Barquero, Sara author Vitelli-Storelli, Facundo author Becerra-Tomas, Nerea author Vazquez-Ruiz, Zenaida author Diaz-Lopez, Andres author Corella, Dolores author Castaner, Olga author Romaguera, Dora author Vioque, Jesus author Alonso-Gomez, Angel María author Warnberg, Julia author Alfredo Martinez, Jose author Serra-Majem, Lluis author Estruch, Ramon author Tinahones, Francisco Jose author Lapetra, Jose author Pinto, Xavier author Tur, Josep A author Lopez-Miranda, Jose author Garcia-Molina, Laura author Delgado-Rodriguez, Miguel author Matia-Martin, Pilar author Daimiel, Lidia author Rubin-Garcia, Maria author Vidal, Josep author Galdon, Alba author Ros, Emilio author Javier Basterra-Gortari, Francisco author Babio, Nancy author Vicente Sorli, Jose author Hernaez, Alvaro author Konieczna, Jadwiga author Notario-Barandiaran, Leyre author Tojal-Sierra, Lucas author Perez-Lopez, Jessica author Abete, Itziar author Alvarez-Perez, Jacqueline author Fernandez-Garcia, Jose Carlos author Santos-Lozano, Jose Manuel author Galera, Ana author Julibert, Alicia author Ruiz-Canela, Miguel author Martinez-Lacruz, Raul author Perez-Vega, Karla-Alejandra author Galmes-Panades, Aina Maria author Pastor-Polo, Concepcion author Moreno-Rodriguez, Anai author Gea, Alfredo author Fito, Montserrat author Lamuela-Raventos, Rosa Maria author Salas-Salvado, Jordi author 2019-11 Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations. Tresserra-Rimbau A, Castro-Barquero S, Vitelli-Storelli F, Becerra-Tomas N, Vazquez-Ruiz Z, Diaz-Lopez A, et al. Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex. Antioxidants. 2019 Nov;8(11):537. 10.3390/antiox8110537 2076-3921 Antioxidants http://hdl.handle.net/20.500.13003/13286 31717390 2-s2.0-85076531826 https://hdl.handle.net/20.500.12105/22765 502268400033 Diet Obesity Flavonoids Catechins Proanthocyanidins Hydroxybenzoic acids Hydroxycinnamic acids Lignans Phenolic acids Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex