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oai:repisalud.isciii.es:20.500.12105/227532024-11-28T21:16:42Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Flores-Holguin, Norma author Frau, Juan author Glossman-Mitnik, Daniel 2024-09-10T13:09:41Z 2024-09-10T13:09:41Z 2019-09 Flores-Holguin N, Frau J, Glossman-Mitnik D. Chemical-Reactivity Properties, Drug Likeness, and Bioactivity Scores of Seragamides A-F Anticancer Marine Peptides: Conceptual Density Functional Theory Viewpoint. Computation. 2019 Sep;7(3):52. 10.3390/computation7030052 2079-3197 Computation http://hdl.handle.net/20.500.13003/15197 2-s2.0-85079792514 https://hdl.handle.net/20.500.12105/22753 487943500018 A methodology based on concepts that arose from Density Functional Theory (CDFT) was chosen for the calculation of global and local reactivity descriptors of the Seragamide family of marine anticancer peptides. Determination of active sites for the molecules was achieved by resorting to some descriptors within Molecular Electron Density Theory (MEDT) such as Fukui functions. The pKas of the six studied peptides were established using a proposed relationship between this property and calculated chemical hardness. The drug likenesses and bioactivity properties of the peptides considered in this study were obtained by resorting to a homology model by comparison with the bioactivity of related molecules in their interaction with different receptors. With the object of analyzing the concept of drug repurposing, a study of potential AGE-inhibition abilities of Seragamides peptides was pursued by comparison with well-known drugs that are already available as pharmaceuticals. eng Seragamides Chemical-reactivity theory Conceptual DFT Global and local reactivity descriptors pKa AGE-inhibition abilities Bioavailability Bioactivity scores Chemical-Reactivity Properties, Drug Likeness, and Bioactivity Scores of Seragamides A-F Anticancer Marine Peptides: Conceptual Density Functional Theory Viewpoint research article