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00925njm 22002777a 4500 dc Papandreou, Christopher author Hernandez-Alonso, Pablo author Bullo, Monica author Ruiz-Canela, Miguel author Yu, Edward author Guasch-Ferre, Marta author Toledo, Estefanía author Dennis, Courtney author Deik, Amy A author Clish, Clary author Razquin, Cristina author Corella, Dolores author Estruch, Ramon author Ros, Emilio author Fito, Montserrat author Aros, Fernando author Fiol Sala, Miquel author Lapetra, Jose author Ruano, Cristina author Liang, Liming author Martinez-Gonzalez, Miguel A author Hu, Frank B author Salas-Salvado, Jordi author 2019-05 Few studies have examined the association of a wide range of metabolites with total and subtypes of coffee consumption. The aim of this study was to investigate associations of plasma metabolites with total, caffeinated, and decaffeinated coffee consumption. We also assessed the ability of metabolites to discriminate between coffee consumption categories. This is a cross-sectional analysis of 1664 participants from the PREDIMED study. Metabolites were semiquantitatively profiled using a multiplatform approach. Consumption of total coffee, caffeinated coffee and decaffeinated coffee was assessed by using a validated food frequency questionnaire. We assessed associations between 387 metabolite levels with total, caffeinated, or decaffeinated coffee consumption (50 mL coffee/day) using elastic net regression analysis. Ten-fold cross-validation analyses were used to estimate the discriminative accuracy of metabolites for total and subtypes of coffee. We identified different sets of metabolites associated with total coffee, caffeinated and decaffeinated coffee consumption. These metabolites consisted of lipid species (e.g., sphingomyelin, phosphatidylethanolamine, and phosphatidylcholine) or were derived from glycolysis (alpha-glycerophosphate) and polyphenol metabolism (hippurate). Other metabolites included caffeine, 5-acetylamino-6-amino-3-methyluracil, cotinine, kynurenic acid, glycocholate, lactate, and allantoin. The area under the curve (AUC) was 0.60 (95% CI 0.56-0.64), 0.78 (95% CI 0.75-0.81) and 0.52 (95% CI 0.49-0.55), in the multimetabolite model, for total, caffeinated, and decaffeinated coffee consumption, respectively. Our comprehensive metabolic analysis did not result in a new, reliable potential set of metabolites for coffee consumption. Papandreou C, Hernandez-Alonso P, Bullo M, Ruiz-Canela M, Yu E, Guasch-Ferre M, et al. Plasma Metabolites Associated with Coffee Consumption: A Metabolomic Approach within the PREDIMED Study. Nutrients. 2019 May;11(5):1032. 10.3390/nu11051032 2072-6643 Nutrients http://hdl.handle.net/20.500.13003/17109 31072000 L2002051248 2-s2.0-85065886222 https://hdl.handle.net/20.500.12105/22740 471021600092 Coffee Caffeine Plasma Metabolomics PREDIMED Plasma Metabolites Associated with Coffee Consumption: A Metabolomic Approach within the PREDIMED Study