2026-06-14T05:06:21Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/227392024-11-28T21:07:28Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16977col_20.500.12105_16972col_20.500.12105_16988
Repisalud
author
Benito, Natividad
author
Mur, Isabel
author
Ribera, Alba
author
Soriano, Alex
author
Rodriguez-Pardo, Dolors
author
Sorli, Luisa
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Cobo, Javier
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Fernandez-Sampedro, Marta
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del Toro, Maria Dolores
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Guio, Laura
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Praena, Julia
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Bahamonde, Alberto
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Riera, Melchor
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Esteban, Jaime
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Mirena Baraia-Etxaburu, Josu
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Martinez-Alvarez, Jesus
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Jover-Saenz, Alfredo
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Dueñas, Carlos
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Ramos, Antonio
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Sobrino, Beatriz
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Euba, Gorane
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Morata, Laura
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Pigrau, Carles
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Horcajada, Juan P
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Coll, Pere
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Crusi, Xavier
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Ariza, Javier
author
REIPI (Spanish Network for Research in Infectious Disease) Group for the Study of Prosthetic Joint Infections/GEIO (Group for the Study of Osteoarticular Infections)
author
SEIMC (Spanish Society of Infectious Diseases and Clinical Microbiology)
2024-09-10T13:09:05Z
2024-09-10T13:09:05Z
2019-05
Benito N, Mur I, Ribera A, Soriano A, Rodriguez-Pardo D, Sorli L, et al. The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms. J Clin Med. 2019 May;8(5):673.
10.3390/jcm8050673
2077-0383
Journal of Clinical Medicine
http://hdl.handle.net/20.500.13003/17153
31086080
L2002006706
2-s2.0-85069898523
https://hdl.handle.net/20.500.12105/22739
470992500108
The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)including multidrug-resistant organisms (MDRO)by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama's scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and positive intraoperative cultures (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: <1 month, 2-3 months, 4-12 months, >12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs.
eng
Prosthetic joint infections
Microbial etiology
Classification schemes for prosthetic joint infections
Antimicrobial empirical treatment
Multidrug-resistant organisms
The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms
research article