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00925njm 22002777a 4500 dc Carpene, Christian author Les, Francisco author Casedas, Guillermo author Peiro, Cecile author Fontaine, Jessica author Chaplin, Alice author Mercader, Josep author Lopez, Victor author 2019-03-26 Studies in animal models of diabetes and obesity have shown that resveratrol mitigates complications of metabolic diseases, beyond those resulting from oxidative stress. Furthermore, results obtained with cultured preadipocytes have also revealed that prolonged resveratrol treatment impairs adipogenesis. Considering the role of adipocytes in the hypertrophy of fat stores, and keeping in mind that insulin is the main trigger of excessive energy storage during post-prandial periods, the present study aimed to investigate how short-term effects of resveratrol can limit glucose disposal in a gut-adipose tissue axis. We found that resveratrol exhibits a more potent inhibitory capacity towards alpha-glucosidase than pancreatic lipase activity. Resveratrol also rapidly blunts glucose transport in mature fat cells by counteracting the effect of insulin and insulin-like lipogenic agents. Within two hours, resveratrol also inhibited the incorporation of glucose into lipids of adipocytes, which was unaffected by membrane cholesterol depletion. Moreover, the comparison between adipocytes with invalidated semicarbazide-sensitive amine oxidase activity and their control, or between resveratrol and several inhibitors, did not indicate that the recently described interaction of resveratrol with amine oxidases was involved in its antilipogenic effect. Caffeine and piceatannol, previously said to interact with glucose carriers, also inhibit lipogenesis in adipocytes, whereas other antioxidant phytochemicals do not reproduce such an antilipogenic effect. This study highlights the diverse first steps by which resveratrol impairs excessive fat accumulation, indicating that this natural molecule and its derivatives deserve further studies to develop their potential anti-obesity properties. Carpene C, Les F, Casedas G, Peiro C, Fontaine J, Chaplin A, et al. Resveratrol Anti-Obesity Effects: Rapid Inhibition of Adipocyte Glucose Utilization. Antioxidants. 2019 Mar 26;8(3):74. 10.3390/antiox8030074 2076-3921 Antioxidants http://hdl.handle.net/20.500.13003/17576 30917543 2-s2.0-85064261406 https://hdl.handle.net/20.500.12105/22736 464313300004 Adipose cells Obesity Amine oxidases Hydrogen peroxide Polyphenols Lipogenesis Resveratrol Anti-Obesity Effects: Rapid Inhibition of Adipocyte Glucose Utilization