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oai:repisalud.isciii.es:20.500.12105/227322024-11-28T20:39:41Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16968

00925njm 22002777a 4500 dc Araceli Marin-Alejandre, Bertha author Abete, Itziar author Cantero, Irene author Riezu-Boj, Jose I author Milagro, Fermin I author Ignacio Monreal, J author Elorz, Mariana author Ignacio Herrero, Jose author Benito-Boillos, Alberto author Quiroga, Jorge author Martinez-Echeverria, Ana author Isidro Uriz-Otano, Juan author Pilar Huarte-Muniesa, Maria author Tur, Josep A author Alfredo Martinez, J author Angeles Zulet, M author 2019-02 The relevance of sleep patterns in the onset or evolution of nonalcoholic fatty liver disease (NAFLD) is still poorly understood. Our aim was to investigate the association between sleep characteristics and hepatic status indicators in obese people with NAFLD compared to normal weight non-NAFLD controls. Ninety-four overweight or obese patients with NAFLD and 40 non-NAFLD normal weight controls assessed by abdominal ultrasonography were enrolled. Hepatic status evaluation considered liver stiffness determined by Acoustic Radiation Force Impulse elastography (ARFI) and transaminases. Additionally, anthropometric measurements, clinical characteristics, and biochemical profiles were determined. Sleep features were evaluated using the Pittsburgh Sleep Quality Index (PSQI). Hepatic status parameters, anthropometric measurements, and clinical and biochemical markers differed significantly in NAFLD subjects compared to controls, as well as sleep efficiency, sleep disturbance score, and sleep quality score. In the NAFLD group, a higher prevalence of short sleep duration (p = 0.005) and poor sleep quality (p = 0.041) were found. Multivariate-adjusted odds ratio (95% confidence interval) for NAFLD considering sleep disturbance was 1.59 (1.11-2.28). Regression models that included either sleep disturbance or sleep quality predicted up to 20.3% and 20.4% of the variability of liver stiffness, respectively, and after adjusting for potential confounders. Current findings suggest that sleep disruption may be contributing to the pathogenesis of NAFLD as well as the alteration of the liver may be affecting sleep patterns. Consequently, sleep characteristics may be added to the list of modifiable behaviors to consider in health promotion strategies and in the prevention and management of NAFLD. Marin-Alejandre BA, Abete I, Cantero I, Riezu-Boj JI, Milagro FI, Monreal JI, et al. Association between Sleep Disturbances and Liver Status in Obese Subjects with Nonalcoholic Fatty Liver Disease: A Comparison with Healthy Controls. Nutrients. 2019 Feb;11(2):322. 10.3390/nu11020322 2072-6643 Nutrients http://hdl.handle.net/20.500.13003/17663 30717355 L2001523733 2-s2.0-85061127703 https://hdl.handle.net/20.500.12105/22732 460829700113 Obesity NAFLD Sleep Sleep duration Sleep disruption Pittsburgh Sleep Quality Index Association between Sleep Disturbances and Liver Status in Obese Subjects with Nonalcoholic Fatty Liver Disease: A Comparison with Healthy Controls