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oai:repisalud.isciii.es:20.500.12105/227262024-11-29T07:42:15Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16968

00925njm 22002777a 4500 dc Cantero, Irene author Elorz, Mariana author Abete, Itziar author Araceli Marin, Bertha author Ignacio Herrero, Jose author Ignacio Monreal, Jose author Benito, Alberto author Quiroga, Jorge author Martinez, Ana author Pilar Huarte, Ma author Isidro Uriz-Otano, Juan author Tur, Josep A author Kearney, John author Alfredo Martinez, J author Angeles Zulet, M author 2019 Introduction: Non-alcoholic fatty liver disease (NAFLD) may progress to steatohepatitis, cirrhosis and complicated hepatocellular carcinoma with defined differential symptoms and manifestations. Objective: To evaluate the fatty liver status by several validated approaches and to compare imaging techniques, lipidomic and routine blood markers with magnetic resonance imaging in adults subjects with non-alcoholic fatty liver disease. Materials and methods: A total of 127 overweight/obese with NAFLD, were parallelly assessed by Magnetic Resonance Imaging (MRI), ultrasonography, transient elastography and a validated metabolomic designed test to diagnose NAFLD in this cross-sectional study. Body composition (DXA), hepatic related biochemical measurements as well as the Fatty Liver Index (FLI) were evaluated. This study was registered as FLiO: Fatty Liver in Obesity study; NCT03183193. Results: The subjects with more severe liver disease were found to have worse metabolic parameters. Positive associations between MRI with inflammatory and insulin biomarkers were found. A linear regression model including ALT, RBP4 and HOMA-IR was able to explain 40.9% of the variability in fat content by MRI. In ROC analyses a combination panel formed of ALT, HOMA-IR and RBP4 followed by ultrasonography, ALT and metabolomic test showed the major predictive ability (77.3%, 74.6%, 74.3% and 71.1%, respectively) for liver fat content. Conclusions: A panel combination including routine blood markers linked to insulin resistance showed highest associations with MRI considered as a gold standard for determining liver fat content. This combination of tests can facilitate the diagnosis of early stages of non-alcoholic liver disease thereby avoiding other invasive and expensive methods. Cantero I, Elorz M, Abete I, Marin BA, Herrero JI, Monreal JI, et al. Ultrasound/Elastography techniques, lipidomic and blood markers compared to Magnetic Resonance Imaging in non-alcoholic fatty liver disease adults. Int J Med Sci. 2019;16(1):75-83. 1449-1907 http://hdl.handle.net/20.500.13003/17271 https://hdl.handle.net/20.500.12105/22726 30662331 10.7150/ijms.28044 International Journal of Medical Sciences 2-s2.0-85060143339 454840700010 L2001352422 MRI Liver fat content Ultrasound ROC FibroScan NAFLD Ultrasound/Elastography techniques, lipidomic and blood markers compared to Magnetic Resonance Imaging in non-alcoholic fatty liver disease adults