2026-05-20T03:50:46Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/227202024-11-28T16:44:15Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16958col_20.500.12105_16967col_20.500.12105_16980
Repisalud author Castano-Nunez, Angel author Montes-Cano, Marco-Antonio author Garcia-Lozano, Jose-Raul author Ortego-Centeno, Norberto author Garcia-Hernandez, Francisco-Jose author Espinosa, Gerard author Grana-Gil, Genaro author Sanchez-Burson, Juan author Julia Benique, Maria Rosa author Solans, Roser author Blanco, Ricardo author Barnosi-Marin, Ana-Celia author Gomez de la Torre, Ricardo author Fanlo Mateo, Patricia author Rodriguez-Carballeira, Monica author Rodriguez-Rodriguez, Luis author Camps, Teresa author Castaneda, Santos author Alegre-Sancho, Juan-Jose author Martin, Javier author Gonzalez-Escribano, Maria-Francisca 2024-09-10T13:08:58Z 2024-09-10T13:08:58Z 2019-11-29 Castano-Nunez A, Montes-Cano MA, Garcia-Lozano JR, Ortego-Centeno N, Garcia-Hernandez FJ, Espinosa G, et al. Association of Functional Polymorphisms of KIR3DL1/DS1 With Behcet's Disease. Front Immunol. 2019 Nov 29;10:2755. 10.3389/fimmu.2019.02755 1664-3224 Frontiers in Immunology http://hdl.handle.net/20.500.13003/12964 31849952 L630179342 2-s2.0-85076837491 https://hdl.handle.net/20.500.12105/22720 502780300001 Behcet's disease (BD) is an immune-mediated vasculitis related to imbalances between the innate and adaptive immune response. Infectious agents or environmental factors may trigger the disease in genetically predisposed individuals. HLA-B51 is the genetic factor stronger associated with the disease, although the bases of this association remain elusive. NK cells have also been implicated in the etiopathogenesis of BD. A family of NK receptors, Killer-cell Immunoglobulin-like Receptor (KIR), with a very complex organization, is very important in the education and control of the NK cells by the union to their ligands, most of them, HLA class I molecules. This study aimed to investigate the contribution of certain KIR functional polymorphisms to the susceptibility to BD. A total of 466 BD patients and 444 healthy individuals were genotyped in HLA class I (A, B, and C). The set of KIR genes and the functional variants of KIR3DL1/DS1 and KIR2DS4 were also determined. Frequency of KIR3DL1*004 was lower in patients than in controls (0.15 vs. 0.20, P = 0.005, Pc = 0.015; OR = 0.70; 95% CI 0.54-0.90) in both B51 positive and negative individuals. KIR3DL1*004, which encodes a misfolded protein, is included in a common telomeric haplotype with only one functional KIR gene, KIR3DL2. Both, KIR3DL1 and KIR3DL2 sense pathogen-associated molecular patterns but they have different capacities to eliminate them. The education of the NK cells depending on the HLA, the balance of KIR3DL1/KIR3DL2 licensed NK cells and the different capacities of these receptors to eliminate pathogens could be involved in the etiopathogenesis of BD. eng Behcet's disease HLA KIR NK cells Functional polymorphisms Association of Functional Polymorphisms of KIR3DL1/DS1 With Behcet's Disease research article