2026-04-29T17:03:12Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/227202024-11-28T16:44:15Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16958col_20.500.12105_16967col_20.500.12105_16980

00925njm 22002777a 4500 dc Castano-Nunez, Angel author Montes-Cano, Marco-Antonio author Garcia-Lozano, Jose-Raul author Ortego-Centeno, Norberto author Garcia-Hernandez, Francisco-Jose author Espinosa, Gerard author Grana-Gil, Genaro author Sanchez-Burson, Juan author Julia Benique, Maria Rosa author Solans, Roser author Blanco, Ricardo author Barnosi-Marin, Ana-Celia author Gomez de la Torre, Ricardo author Fanlo Mateo, Patricia author Rodriguez-Carballeira, Monica author Rodriguez-Rodriguez, Luis author Camps, Teresa author Castaneda, Santos author Alegre-Sancho, Juan-Jose author Martin, Javier author Gonzalez-Escribano, Maria-Francisca author 2019-11-29 Behcet's disease (BD) is an immune-mediated vasculitis related to imbalances between the innate and adaptive immune response. Infectious agents or environmental factors may trigger the disease in genetically predisposed individuals. HLA-B51 is the genetic factor stronger associated with the disease, although the bases of this association remain elusive. NK cells have also been implicated in the etiopathogenesis of BD. A family of NK receptors, Killer-cell Immunoglobulin-like Receptor (KIR), with a very complex organization, is very important in the education and control of the NK cells by the union to their ligands, most of them, HLA class I molecules. This study aimed to investigate the contribution of certain KIR functional polymorphisms to the susceptibility to BD. A total of 466 BD patients and 444 healthy individuals were genotyped in HLA class I (A, B, and C). The set of KIR genes and the functional variants of KIR3DL1/DS1 and KIR2DS4 were also determined. Frequency of KIR3DL1*004 was lower in patients than in controls (0.15 vs. 0.20, P = 0.005, Pc = 0.015; OR = 0.70; 95% CI 0.54-0.90) in both B51 positive and negative individuals. KIR3DL1*004, which encodes a misfolded protein, is included in a common telomeric haplotype with only one functional KIR gene, KIR3DL2. Both, KIR3DL1 and KIR3DL2 sense pathogen-associated molecular patterns but they have different capacities to eliminate them. The education of the NK cells depending on the HLA, the balance of KIR3DL1/KIR3DL2 licensed NK cells and the different capacities of these receptors to eliminate pathogens could be involved in the etiopathogenesis of BD. Castano-Nunez A, Montes-Cano MA, Garcia-Lozano JR, Ortego-Centeno N, Garcia-Hernandez FJ, Espinosa G, et al. Association of Functional Polymorphisms of KIR3DL1/DS1 With Behcet's Disease. Front Immunol. 2019 Nov 29;10:2755. 10.3389/fimmu.2019.02755 1664-3224 Frontiers in Immunology http://hdl.handle.net/20.500.13003/12964 31849952 L630179342 2-s2.0-85076837491 https://hdl.handle.net/20.500.12105/22720 502780300001 Behcet's disease HLA KIR NK cells Functional polymorphisms Association of Functional Polymorphisms of KIR3DL1/DS1 With Behcet's Disease