2026-07-21T15:39:23Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/226692024-11-28T22:45:29Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Vicens-Caldentey, Caterina author Leiva Rus, Alfonso author Bejarano, Ferran author Sempere, Ermengol author Maria Rodriguez-Rincon, Raquel author Fiol, Francisca author Mengual, Marta author Ajenjo, Asuncion author Do Pazo Oubina, Fernando author Mateu, Catalina author Folch, Silvia author Alegret, Santiago author Maria Coll, Jose author Martin-Rabadan Muro, Maria author Socias, Isabel author 2019-06 Introduction: Benzodiazepines (BZDs) are mainly used to treat anxiety and sleep disorders, and are often prescribed for long durations, even though prescription guidelines recommend short-term use due to the risk of dependence, cognitive impairment, and falls and fractures. Education of general practitioners (GPs) regarding the prescription of BZDs may reduce the overuse and of these drugs. The aims of this study are to analyse the effectiveness of an intervention targeted to GPs to reduce BZD prescription and evaluate the implementation process. Methods and analysis: The healthcare centres in three regions of Spain (Balearic Islands, Catalonia and Community of Valencia) will be randomly allocated to receive a multifactorial intervention or usual care (control). GPs in the intervention group will receive a 2-hour workshop about best-practice regarding BZD prescription and BZD deprescribing, monthly feedback about their BZD prescribing practices and access to a support web page. Outcome measures for each GP are the defined daily dosage per 1000 inhabitants per day and the proportion of long-term BZD users at 12 months. Data will be collected from the electronic prescription database of the public health system, and will be subjected to intention-to-treat analysis. Implementation will be evaluated by mixed methods following the five domains of the Consolidated Framework For Implementation Research. Ethics and dissemination This study was approved by the Balearic Islands Ethical Committee of Clinical Research (IB3065/ 15), l'IDIAP Jordi Gol Ethical Committee of Clinical Research (PI 15/ 0148) and Valencia Primary Care Ethical Committee of Clinical Research (P16/ 024). The results will be submitted for publication in peer-reviewed journals. Vicens Caldentey C, Leiva A, Bejarano F, Sempere E, Maria Rodriguez-Rincon R, Fiol F, et al. Intervention to reduce benzodiazepine prescriptions in primary care, study protocol of a hybrid type 1 cluster randomised controlled trial: the BENZORED study. BMJ Open. 2019 Jun;9(1):e022046. 10.1136/bmjopen-2018-022046 2044-6055 BMJ Open http://hdl.handle.net/20.500.13003/17147 30705235 L626162477 2-s2.0-85060914079 https://hdl.handle.net/20.500.12105/22669 471116800030 Intervention to reduce benzodiazepine prescriptions in primary care, study protocol of a hybrid type 1 cluster randomised controlled trial: the BENZORED study