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Repisalud author Albasanz-Puig, Adaia author Gudiol, Carlota author Parody, Rocio author Tebe, Cristian author Akova, Murat author Araos, Rafael author Bote, Anna author Brunel, Anne-Sophie author Calik, Sebnem author Drgona, Lubos author Garcia, Estefania author Hemmati, Philipp author Herrera, Fabian author Ibrahim, Karim Yaqub author Isler, Burcu author Kanj, Souha author Kern, Winfried author Maestro de la Calle, Guillermo author Manzur, Adriana author Ivan Marin, Jorge author Marquez-Gomez, Ignacio author Martín-Dávila, Pilar author Mikulska, Malgorzata author Montejo, Jose Miguel author Montero, Milagros author Paz Morales, Hugo Manuel author Morales, Isabel author Novo, Andrés author Oltolini, Chiara author Peghin, Maddalena author del Pozo, Jose Luis author Puerta-Alcalde, Pedro author Ruiz-Camps, Isabel author Resat Sipahi, Oguz author Tilley, Robert author Yanez, Lucrecia author Ribeiro Gomes, Marisa Zenaide author Carratalà, Jordi author Cuervo, Guillermo author Escrihuela-Vidal, Francesc author Tubau, Fe author Rodriguez Arias, Marisol author Merve Ayaz, Caglayan author Munita, Jose author Gasch, Oriol author Capilla, Silvia author Bochud, Pierre-Yves author Manuel, Oriol author Torre-Cisneros, Julian author Tabares, Salvador author Serrano Lopez, Josefina author Maschmeyer, Georg author Torres, Diego author Abdala, Edson author Bittencourt, Driele Peixoto author El Zein, Saeed author Jabbour, Jean-Francois author Bertz, Hartmut author Peyerl-Hoffmann, Gabriele author Lizasoain, Manuel author Aguado, José María author Clemencia Correa, Lina author Palop, Begona author Fortun, Jesus author Magnasco, Laura author Cespedes, Roberto author Lopez-Soria, Leire author Pablo Horcajada, Juan author Montaguti, Mia Hold author de Cueto, Marina author Rodriguez-Bano, Jesus author Greco, Raffaella author Cichero, Paola author Bassetti, Matteo author Castaldo, Nadia author Sangro del Alcazar, Paloma author Cardozo, Celia author Garcia-Vidal, Carolina author Aguilar-Company, Juan author Larrosa, Nieves author Uyan-Onal, Ayse author Nazli-Zeka, Arzu author Vasconcelos de Freitas, Wania author da Silva Machado, Amanda Aparecida author IRONIC Study Grp 2024-09-10T13:06:56Z 2024-09-10T13:06:56Z 2019-05 Albasanz-Puig A, Gudiol C, Parody R, Tebe C, Akova M, Araos R, et al. Impact of antibiotic resistance on outcomes of neutropenic cancer patients with Pseudomonas aeruginosa bacteraemia (IRONIC study): study protocol of a retrospective multicentre international study. BMJ Open. 2019 May;9(5):e025744. 2044-6055 http://hdl.handle.net/20.500.13003/17150 https://hdl.handle.net/20.500.12105/22667 31129580 10.1136/bmjopen-2018-025744 BMJ Open 2-s2.0-85066845183 471192800144 L627799701 Introduction: Pseudomonas aeruginosa (PA) has historically been one of the major causes of severe sepsis and death among neutropenic cancer patients. There has been a recent increase of multidrug-resistant PA (MDRPA) isolates that may determine a worse prognosis, particularly in immunosuppressed patients. The aim of this study is to establish the impact of antibiotic resistance on the outcome of neutropenic onco-haematological patients with PA bacteraemia, and to identify the risk factors for MDRPA bacteraemia and mortality. Methods and analysis: This is a retrospective, observational, multicentre, international study. All episodes of PA bacteraemia occurring in neutropenic onco-haematological patients followed up at the participating centres from 1 January 2006 to 31 May 2018 will be retrospectively reviewed. The primary end point will be overall case-fatality rate within 30 days of onset of PA bacteraemia. The secondary end points will be to describe the following: the incidence and risk factors for multidrug-resistant and extremely drug-resistant PA bacteraemia (by comparing the episodes due to susceptible PA with those produced by MDRPA), the efficacy of ceftolozane/tazobactam, the rates of persistent bacteraemia and bacteraemia relapse and the risk factors for very early (48 hours), early (7 days) and overall (30 days) case-fatality rates. Ethics and dissemination The Clinical Research Ethics Committee of Bellvitge University Hospital approved the protocol of the study at the primary site. To protect personal privacy, identifying information of each patient in the electronic database will be encrypted. The processing of the patients' personal data collected in the study will comply with the Spanish Data Protection Act of 1998 and with the European Directive on the privacy of data. All data collected, stored and processed will be anonymised. Results will be reported at conferences and in peer-reviewed publications. eng Impact of antibiotic resistance on outcomes of neutropenic cancer patients with Pseudomonas aeruginosa bacteraemia (IRONIC study): study protocol of a retrospective multicentre international study research article