2026-04-29T04:09:10Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/226622024-11-29T07:06:08Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Roca, Miquel author Riera-López Del Amo, Antonio author Riera-Serra, Pau author Angeles Perez-Ara, Ma author Castro, Adoración author Roman Juan, J author Garcia Toro, Mauro author García-Pazo, Patricia author Gili, Margalida author 2019-08-16 Background Suicide is a serious public health concern. Depression is the main gateway to suicidal behavior. The already established relationship between depression and suicidal risk should now focus on the investigation of more specific factors: recent studies have suggested an association between vulnerability to suicidal behavior and neurocognitive alterations, a nuclear symptom of depression. This project aims to identify alterations in the Executive Functions (EF) of patients suffering a first depressive episode that might constitute a risk factor for suicidal ideation, suicidal attempts and suicide, to allow for more adequate suicide prevention. Methods Prospective longitudinal design involving two groups (first depressive episodes with and without alterations in their EF) and four repeated measures (0, 6, 12 and 24 months). The estimated minimum sample size is 216 subjects. The variables and measurement instruments will include socio-demographic variables, clinical variables (age of illness onset, family and personal antecedents, psychopathological and medical comorbidity, suicidal ideation, suicide attempts and completed suicides, severity of depression, including melancholic or atypical, remission of the depressive episode), and neuropsychological variables (EF and decision-making processes evaluated through the Cambridge Neuropsychological Test Automated Battery (CANTAB)). Discussion First and foremost, the identification of clinical and neuropsychological risk factors associated with suicidal behavior will open the possibility to prevent such behavior in patients with a first depressive episode in the context of clinical practice. Secondly, interventions aimed at cognitive impairment (in particular: EF) derived from the study may be incorporated into strategies for the prevention of suicidal behavior. Finally, impaired neurocognitive function (even in early stages) could become an identifiable endophenotype or marker in clinical and neurobiological studies about suicidal behavior in depressive patients. Roca M, Riera-Lopez Del Amo A, Riera-Serra P, Perez Ara MA, Castro Garcia AC, Roman Juan J, et al. Suicidal risk and executive functions in major depressive disorder: a study protocol. BMC Psychiatry. 2019 Aug 16;19(1):253. http://hdl.handle.net/20.500.13003/15408 https://hdl.handle.net/20.500.12105/22662 31420027 10.1186/s12888-019-2233-1 1471-244X BMC Psychiatry 2-s2.0-85070896437 481743500001 L628924222 Major depressive disorder Suicide Suicidal attempt Suicidal ideation Executive functions Longitudinal study Suicidal risk and executive functions in major depressive disorder: a study protocol