2026-07-21T13:50:54Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/226612025-05-07T10:23:49Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc de Mendoza, Carmen author Roc, Lourdes author Benito, Rafael author Reina, Gabriel author Ramos, Jose Manuel author Gomez, Cesar author Aguilera, Antonio author Rodriguez-Iglesias, Manuel author Garcia-Costa, Juan author Fernandez-Alonso, Miriam author Soriano, Vicente author Rodriguez, C author Vera, M author Del Romero, Jorge author Marcaida, G author Ocete, M. D author Caballero, E author Molina, I author Rodriguez-Calvino, J. J author Navarro, D author Rivero, C author Vilarino, M. D author Algarate, S author Gil, J author Ortíz de Lejarazu, Raúl author Rojo, S author Eiros, José María author San Miguel, A author Manzardo, C author Miro, J. M author Garcia, Josefina author Paz, I author Poveda, E author Calderon, E author Escudero, Desamparados author Trigo, M author Diz, J author Garcia-Campello, M author Hernandez-Betancor, A author Martin, A. M author Gimeno, A author Gutierrez, F author Rodriguez, J. C author Sanchez, V author Gomez-Hernando, C author Cilla, G author Perez-Trallero, E author Lopez-Aldeguer, J author Fernandez-Pereira, Luis author Niubo, J author Hernandez, M author Lopez-Lirola, A. M author Gomez-Sirvent, J. L author Force, Lluis author Cifuentes Luna, Carmen author Perez, S author Morano, L author Raya, C author Gonzalez-Praetorius, A author Perez-Saenz, José Luis author Penaranda, M author Hernaez-Crespo, S author Montejo, J. M author Martinez-Sapina, A author Viciana, I author Cabezas, T author Lozano, A author Fernandez, J. M author Garcia-Bermejo, I author Gaspar, G author Garcia, R author Gorgolas, M author Vegas, C author Blas, J author Miralles, P author Valeiro, M author Aldámiz-Echevarria, Teresa author Margall, N author Guardia, C author do Pico, E author Polo, I author Aguinaga, A author Ezpeleta, Carmen author Sauleda, S author Piron, M author Gonzalez, R author Barea, L author Jimenez, A author Blanco, L author Suarez, A author Rodríguez-Avial, Icíar author Perez-Rivilla, A author Parra, P author Fernández, Margarita author Trevino, A author Requena, S author Benitez-Gutierrez, L author Cuervas-Mons, V author Barreiro, P author Soriano, V author Corral, O author Gomez-Gallego, F author Spanish HTLV Network author 2019-08-09 Background: HTLV-1 infection is a neglected disease, despite infecting 10-15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated illnesses due to immunosuppression, screening is being widely considered in the transplantation setting. Herein, we report the experience with universal HTLV testing of donors and recipients of solid organ transplants in a survey conducted in Spain. Methods: All hospitals belonging to the Spanish HTLV network were invited to participate in the study. Briefly, HTLV antibody screening was performed retrospectively in all specimens collected from solid organ donors and recipients attended since the year 2008. Results: A total of 5751 individuals were tested for HTLV antibodies at 8 sites. Donors represented 2312 (42.2%), of whom 17 (0.3%) were living kidney donors. The remaining 3439 (59.8%) were recipients. Spaniards represented nearly 80%. Overall, 9 individuals (0.16%) were initially reactive for HTLV antibodies. Six were donors and 3 were recipients. Using confirmatory tests, HTLV-1 could be confirmed in only two donors, one Spaniard and another from Colombia. Both kidneys of the Spaniard were inadvertently transplanted. Subacute myelopathy developed within 1 year in one recipient. The second recipient seroconverted for HTLV-1 but the kidney had to be removed soon due to rejection. Immunosuppression was stopped and 3 years later the patient remains in dialysis but otherwise asymptomatic. Conclusion: The rate of HTLV-1 is low but not negligible in donors/recipients of solid organ transplants in Spain. Universal HTLV screening should be recommended in all donor and recipients of solid organ transplantation in Spain. Evidence is overwhelming for very high virus transmission and increased risk along with the rapid development of subacute myelopathy. De Mendoza C, Roc L, Benito R, Reina G, Ramos JM, Gomez C, et al. HTLV-1 infection in solid organ transplant donors and recipients in Spain. BMC Infect Dis. 2019 Aug 09;19(1):706. 10.1186/s12879-019-4346-z 1471-2334 BMC Infectious Diseases http://hdl.handle.net/20.500.13003/15442 31399112 L628847268 2-s2.0-85070476913 https://hdl.handle.net/20.500.12105/22661 480544400003 HTLV-1 Transplantation Screening Tropical spastic paraparesis Adult T-cell leukaemia Immunosuppression HTLV-1 infection in solid organ transplant donors and recipients in Spain