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00925njm 22002777a 4500 dc Aguado, José María author Silva, JT author Fernandez-Ruiz, Mario author Cordero, Elisa author Fortun, Jesus author Gudiol, C author Martinez-Martinez, L author Vidal, E author Almenar, L author Almirante, B author Canton, R author Carratala, J author Caston, JJ author Cercenado, E author Cervera, C author Cisneros, JM author Crespo-Leiro, MG author Cuervas-Mons, V author Elizalde-Fernandez, J author Farinas Alvarez, Carmen author Gavalda, J author Goyanes, MJ author Gutierrez-Gutierrez, B author Hernandez, D author Len, O author Lopez-Andujar, R author Lopez-Medrano, F author Martín-Dávila, Pilar author Montejo, M author Moreno, A author Oliver, Antonio author Pascual, A author Pérez-Nadales, Elena author Roman-Broto, A author San-Juan, R author Seron, D author Sole-Jover, A author Valerio, M author Munoz, P author Torre-Cisneros, J author Spanish Soc Transplantat SET author Grp Study Infection Transplantat S author Spanish Network Res Infe author 2018-01 Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant (MDR) Gram-negative bacilli (GNB), as they are frequently exposed to antibiotics and the healthcare setting, and are regulary subject to invasive procedures. Nevertheless, no recommendations concerning prevention and treatment are available. A panel of experts revised the available evidence; this document summarizes their recommendations: (1) it is important to characterize the isolate's phenotypic and genotypic resistance profile; (2) overall, donor colonization should not constitute a contraindication to transplantation, although active infected kidney and lung grafts should be avoided; (3) recipient colonization is associated with an increased risk of infection, but is not a contraindication to transplantation; (4) different surgical prophylaxis regimens are not recommended for patients colonized with carbapenem-resistant GNB; (5) timely detection of carriers, contact isolation precautions, hand hygiene compliance and antibiotic control policies are important preventive measures; (6) there is not sufficient data to recommend intestinal decolonization; (7) colonized lung transplant recipients could benefit from prophylactic inhaled antibiotics, specially for Pseudomonas aeruginosa; (8) colonized SOT recipients should receive an empirical treatment which includes active antibiotics, and directed therapy should be adjusted according to susceptibility study results and the severity of the infection. Aguado J. M., Silva J. T., Fernandez-Ruiz M., Cordero E., Fortun J., Gudiol C., et al. Management of multidrug resistant Gram-negative bacilli infections in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations. Transplant Rev. 2018 Jan;32(1):36-57. Epub 2017 Jul 26. 10.1016/j.trre.2017.07.001 0955-470X Transplantation Reviews http://hdl.handle.net/20.500.13003/9470 28811074 L618020670 2-s2.0-85028328902 https://hdl.handle.net/20.500.12105/22640 419263200005 Management of multidrug resistant Gram-negative bacilli infections in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations