2026-04-29T12:24:07Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/226382025-05-05T09:22:39Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16961col_20.500.12105_16962col_20.500.12105_16967col_20.500.12105_16968

00925njm 22002777a 4500 dc Cantero, Irene author Abete, Itziar author Babio, Nancy author Aros, Fernando author Corella, Dolores author Estruch, Ramon author Fito, Montserrat author Hebert, James R author Angel Martinez-Gonzalez, M author Pinto, Xavier author Puy-Portillo, María author Ruiz-Canela, Miguel author Shivappa, Nitin author Warnberg, Julia author Gomez-Gracia, Enrique author Tur, Josep A author Salas-Salvado, Jordi author Angeles Zulet, M author Alfredo Martinez, J author 2018-10 Background & aims: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. Methods: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean +/- SD age: 67.0 +/- 5.0 y, 55% females) from the PREDIMED (PREvencion con Dleta MEDiterranea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-alpha and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated. Results: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern. Conclusions: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity. Cantero Irene, Abete Itziar, Babio Nancy, Aros Fernando, Corella Dolores, Estruch Ramon, et al. Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial. Clin Nutr. 2018 Oct;37(5):1736-1743. Epub 2017 Jul 6. 10.1016/j.clnu.2017.06.027 1532-1983 0261-5614 Clinical Nutrition http://hdl.handle.net/20.500.13003/9091 28734553 L617421495 2-s2.0-85024863691 https://hdl.handle.net/20.500.12105/22638 447578700041 Liver Diet Inflammation NAFLD Obesity Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial