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oai:repisalud.isciii.es:20.500.12105/226292024-11-28T20:26:17Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16980col_20.500.12105_16988
Repisalud author Zapata-Wainberg, G author Quintas, S author Ximenez-Carrillo Rico, A author Benavente Fernandez, L author Masjuan Vallejo, J author Gallego Cullere, Jaime author Freijo Guerrero, Maria del Mar author Egido, Jose author Gomez Sanchez, JC author Martinez Domeno, A author Purroy, F author Vives Pastor, Barbara author Rodriguez Yanez, M author Vivancos, J author Grp Investigadores Estudio TAC 2024-09-06T09:56:43Z 2024-09-06T09:56:43Z 2018-09 Zapata-Wainberg G, Quintas S, Ximenez-Carrillo Rico A, Benavente Fernandez L, Masjuan Vallejo J, Gallego Cullere J, et al. Prognostic factors and analysis of mortality due to brain haemorrhages associated with vitamin K antagonist oral anticoagulants. Results from the TAC registry. Neurologia. 2018 Sep;33(7):419-26. Epub 2016 Sep 16. 10.1016/j.nrl.2016.07.005 1578-1968 0213-4853 Neurologia http://hdl.handle.net/20.500.13003/17449 27645776 L613216120 2-s2.0-84994772128 https://hdl.handle.net/20.500.12105/22629 444418800001 Introduction: Intracranial haemorrhages (ICH) represent a severe and frequently lethal complication in patients treated with vitamin K antagonists (VKA). The purpose of our study is to describe the factors and clinical features associated with mortality in these patients. Methods: We conducted an observational, retrospective, multi-centre study based on prospective stroke registries in Spain. We included all patients admitted to neurology departments during a one-year period who met the following inclusion criteria: being 18 or older, having a diagnosis of ICH, and receiving VKA. Clinical and radiological parameters and 3-month outcomes were analysed. Results: A total of 235 patients from 21 hospitals were included. Mortality rate at 90 days was 42.6%. Bivariate analysis showed a significant association between death and the following factors: median NIHSS score at admission (5 [IQR = 9] vs 17 [IQR = 14] points, P < .01) and presence of an extensive hemispheric haemorrhage (4.9% vs 35%, P < .01; chi(2)). Extensive hemispheric haemorrhages, in addition to being the most lethal type, were associated with a shorter time to death (mean of 16.5 days; 95% CI: 7.1-26). A logistic regression model showed that only baseline NIHSS scores independently predicted death (odds ratio =1.13 [95% CI: 1.08-1.17] for each point in the scale). Conclusion: ICH in patients treated with VKA is associated with high mortality rates; mortality in these patients is mainly and independently associated with the clinical situation at stroke onset. spa Intracranial haemorrhage Oral anticoagulants Acenocoumarol Warfarin Mortality Prognostic factors and analysis of mortality due to brain haemorrhages associated with vitamin K antagonist oral anticoagulants. Results from the TAC registry research article