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oai:repisalud.isciii.es:20.500.12105/226292024-11-28T20:26:17Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16980col_20.500.12105_16988

00925njm 22002777a 4500 dc Zapata-Wainberg, G author Quintas, S author Ximenez-Carrillo Rico, A author Benavente Fernandez, L author Masjuan Vallejo, J author Gallego Cullere, Jaime author Freijo Guerrero, Maria del Mar author Egido, Jose author Gomez Sanchez, JC author Martinez Domeno, A author Purroy, F author Vives Pastor, Barbara author Rodriguez Yanez, M author Vivancos, J author Grp Investigadores Estudio TAC author 2018-09 Introduction: Intracranial haemorrhages (ICH) represent a severe and frequently lethal complication in patients treated with vitamin K antagonists (VKA). The purpose of our study is to describe the factors and clinical features associated with mortality in these patients. Methods: We conducted an observational, retrospective, multi-centre study based on prospective stroke registries in Spain. We included all patients admitted to neurology departments during a one-year period who met the following inclusion criteria: being 18 or older, having a diagnosis of ICH, and receiving VKA. Clinical and radiological parameters and 3-month outcomes were analysed. Results: A total of 235 patients from 21 hospitals were included. Mortality rate at 90 days was 42.6%. Bivariate analysis showed a significant association between death and the following factors: median NIHSS score at admission (5 [IQR = 9] vs 17 [IQR = 14] points, P < .01) and presence of an extensive hemispheric haemorrhage (4.9% vs 35%, P < .01; chi(2)). Extensive hemispheric haemorrhages, in addition to being the most lethal type, were associated with a shorter time to death (mean of 16.5 days; 95% CI: 7.1-26). A logistic regression model showed that only baseline NIHSS scores independently predicted death (odds ratio =1.13 [95% CI: 1.08-1.17] for each point in the scale). Conclusion: ICH in patients treated with VKA is associated with high mortality rates; mortality in these patients is mainly and independently associated with the clinical situation at stroke onset. Zapata-Wainberg G, Quintas S, Ximenez-Carrillo Rico A, Benavente Fernandez L, Masjuan Vallejo J, Gallego Cullere J, et al. Prognostic factors and analysis of mortality due to brain haemorrhages associated with vitamin K antagonist oral anticoagulants. Results from the TAC registry. Neurologia. 2018 Sep;33(7):419-26. Epub 2016 Sep 16. 10.1016/j.nrl.2016.07.005 1578-1968 0213-4853 Neurologia http://hdl.handle.net/20.500.13003/17449 27645776 L613216120 2-s2.0-84994772128 https://hdl.handle.net/20.500.12105/22629 444418800001 Intracranial haemorrhage Oral anticoagulants Acenocoumarol Warfarin Mortality Prognostic factors and analysis of mortality due to brain haemorrhages associated with vitamin K antagonist oral anticoagulants. Results from the TAC registry