2026-04-27T03:43:11Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/226102024-11-29T04:30:54Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Uriol Rivera, Miguel G author Cabello Pelegrin, Sheila author Ballester Ruiz, Maria del Carmen author López Andrade, Bernardo author Lumbreras, Javier author Obrador-Mulet, Aina author Perez Montana, Albert author Ferreruela Serlavos, Mireia author Ayestaran Rota, Jose Ignacio author Ferrer Balaguer, Juana Maria author Delgado Sanchez, Olga author Pallares-Ferreres, Lucio author Mas Bonet, Antonio author Picado Valles, Maria Jose author Ruiz de Gopegui, Rosa author 2018-11-02 Background: Thrombotic microangiopathy (TMA) is an important complication associated with several diseases that are rare and life-threatening. TMA is common to thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). TTP is defined by a severe deficiency of ADAMTS13, and early treatment is associated with good prognosis. The diagnosis of HUS can be difficult due to the potential multiple etiologies, and the best treatment option in most cases is not well-established yet. The implementation of a multidisciplinary team (MDT) could decrease the time to diagnosis and treatment for HUS and may improve the outcomes of these patients. Objective: To determine the impact of MDT on morbidity and mortality [death or chronic renal replacement therapy (CRRT) requirements], incidence and response time [(RT) defined as the period between hospital admission and the first day of direct therapy administration], length of stay at an intensive care unit (ICU-LOS) and total hospitalization (T-LOS) were also assessed. Methods We compared a pre-MDT implementation period (from January/2008 to May/2016) versus post-MDT period (from May/2016 to December/2016). The screening TMA diagnosis was made according the following criteria: hemolytic anemia, thrombocytopenia and acute renal damage and without ADAMTS13 deficiency. An online chat was implemented to provide instant medical information. Results: Twenty-eight patients were included. The incidence changed from 2.3 cases/pre-MDT: (all cases: n = 18) to 10 cases/year post-MDT (all cases: n = 10). Two patients died in pre-MDT and post- MDT (11% versus 20%, P= 0.60). From pre-MDT, the number of patients who required CRRT by post-MDT decreased from 7 (39%) to 0, P= 0.03. Similarly, RT, ICULOS and T-LOS [median(p25-p75)] decreased from 10 (2-12) days to 0.5 (0-1.5) days, P= 0.04, from 16 (9-30) days to 10 (4-13) days, P= 0.01 and from 33 (22-53) days to 16 (1232) days, P < 0.01, respectively. Conclusion: MDT implementation was associated with a greater number of patients who meet TMA criteria. A decrease in the RT and T-LOS periods were observed and associated with better outcomes in these patients. Uriol Rivera MG, Cabello Pelegrin S, Ballester Ruiz MC, Lopez-Andrade B, Lumbreras Fernández J, Obrador Mulet A, et al. Impact of a multidisciplinary team for the management of thrombotic microangiopathy. PLoS One. 2018 Nov 02;13(11):e0206558. 1932-6203 http://hdl.handle.net/20.500.13003/9030 https://hdl.handle.net/20.500.12105/22610 30388144 10.1371/journal.pone.0206558 PloS One 2-s2.0-85056069800 449289800042 L624736664 Impact of a multidisciplinary team for the management of thrombotic microangiopathy