2026-06-14T03:46:30Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/225902024-11-29T04:40:44Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16968
Repisalud
author
Galarregui, Cristina
author
Angeles Zulet, Maria
author
Cantero, Irene
author
Araceli Marin-Alejandre, Bertha
author
Ignacio Monreal, Jose
author
Elorz, Mariana
author
Benito-Boillos, Alberto
author
Ignacio Herrero, Jose
author
Tur, Josep A
author
Abete, Itziar
author
Alfredo Martinez, Jose
2024-09-06T09:56:01Z
2024-09-06T09:56:01Z
2018-11
Galarregui C, Zulet MA, Cantero I, Marin-Alejandre BA, Monreal JI, Elorz M, et al. Interplay of Glycemic Index, Glycemic Load, and Dietary Antioxidant Capacity with Insulin Resistance in Subjects with a Cardiometabolic Risk Profile. Int J Mol Sci. 2018 Nov;19(11):3662.
10.3390/ijms19113662
1422-0067
International Journal of Molecular Sciences
http://hdl.handle.net/20.500.13003/9038
30463312
L625048722
2-s2.0-85056976902
https://hdl.handle.net/20.500.12105/22590
451528500378
Background: Dietary total antioxidant capacity (TAC), glycemic index (GI), and glycemic load (GL) are accepted indicators of diet quality, which have an effect on diet-disease relationships. The aim of this study was to evaluate potential associations of dietary TAC, GI, and GL with variables related to nutritive status and insulin resistance (IR) risk in cardiometabolic subjects. Methods: A total of 112 overweight or obese adults (age: 50.8 +/- 9 years old) were included in the trial. Dietary intake was assessed by a validated 137-item food frequency questionnaire (FFQ), which was also used to calculate the dietary TAC, GI, and GL. Anthropometrics, blood pressure, body composition by dual-energy X-ray absorptiometry (DXA), glycemic and lipid profiles, C-reactive protein (CRP), as well as fatty liver quantification by magnetic resonance imaging (MRI) were assessed. Results: Subjects with higher values of TAC had significantly lower circulating insulin concentration and homeostatic model assessment of insulin resistance (HOMA-IR). Participants with higher values of HOMA-IR showed significantly higher GI and GL. Correlation analyses showed relevant inverse associations of GI and GL with TAC. A regression model evidenced a relationship of HOMA-IR with TAC, GI, and GL. Conclusion: This data reinforces the concept that dietary TAC, GI, and GL are potential markers of diet quality, which have an impact on the susceptible population with a cardiometabolic risk profile.
eng
Antioxidants
Glucose
Diet
Diabetes
Precision nutrition
Interplay of Glycemic Index, Glycemic Load, and Dietary Antioxidant Capacity with Insulin Resistance in Subjects with a Cardiometabolic Risk Profile
research article