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oai:repisalud.isciii.es:20.500.12105/225902024-11-29T04:40:44Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16968

00925njm 22002777a 4500 dc Galarregui, Cristina author Angeles Zulet, Maria author Cantero, Irene author Araceli Marin-Alejandre, Bertha author Ignacio Monreal, Jose author Elorz, Mariana author Benito-Boillos, Alberto author Ignacio Herrero, Jose author Tur, Josep A author Abete, Itziar author Alfredo Martinez, Jose author 2018-11 Background: Dietary total antioxidant capacity (TAC), glycemic index (GI), and glycemic load (GL) are accepted indicators of diet quality, which have an effect on diet-disease relationships. The aim of this study was to evaluate potential associations of dietary TAC, GI, and GL with variables related to nutritive status and insulin resistance (IR) risk in cardiometabolic subjects. Methods: A total of 112 overweight or obese adults (age: 50.8 +/- 9 years old) were included in the trial. Dietary intake was assessed by a validated 137-item food frequency questionnaire (FFQ), which was also used to calculate the dietary TAC, GI, and GL. Anthropometrics, blood pressure, body composition by dual-energy X-ray absorptiometry (DXA), glycemic and lipid profiles, C-reactive protein (CRP), as well as fatty liver quantification by magnetic resonance imaging (MRI) were assessed. Results: Subjects with higher values of TAC had significantly lower circulating insulin concentration and homeostatic model assessment of insulin resistance (HOMA-IR). Participants with higher values of HOMA-IR showed significantly higher GI and GL. Correlation analyses showed relevant inverse associations of GI and GL with TAC. A regression model evidenced a relationship of HOMA-IR with TAC, GI, and GL. Conclusion: This data reinforces the concept that dietary TAC, GI, and GL are potential markers of diet quality, which have an impact on the susceptible population with a cardiometabolic risk profile. Galarregui C, Zulet MA, Cantero I, Marin-Alejandre BA, Monreal JI, Elorz M, et al. Interplay of Glycemic Index, Glycemic Load, and Dietary Antioxidant Capacity with Insulin Resistance in Subjects with a Cardiometabolic Risk Profile. Int J Mol Sci. 2018 Nov;19(11):3662. 10.3390/ijms19113662 1422-0067 International Journal of Molecular Sciences http://hdl.handle.net/20.500.13003/9038 30463312 L625048722 2-s2.0-85056976902 https://hdl.handle.net/20.500.12105/22590 451528500378 Antioxidants Glucose Diet Diabetes Precision nutrition Interplay of Glycemic Index, Glycemic Load, and Dietary Antioxidant Capacity with Insulin Resistance in Subjects with a Cardiometabolic Risk Profile