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00925njm 22002777a 4500 dc Lopez, Nora author Sanchez, Juana author Palou, Andreu author Serra, Francisca author 2018-01 Early nutrition plays an important role in development and may constitute a relevant contributor to the onset of obesity in adulthood. The aim of this study was to evaluate the long-term impact of maternal leucine (Leu) supplementation during lactation on progeny in rats. A chow diet, supplemented with 2% Leu, was supplied during lactation (21 days) and, from weaning onwards, was replaced by a standard chow diet. Then, at adulthood (6 months of age), this was replaced with hypercaloric diets (either with high-fat (HF) or high-carbohydrate (HC) content), for two months, to induce obesity. Female offspring from Leu-supplemented dams showed higher increases in body weight and in body fat (62%) than their respective controls; whereas males were somehow protected (15% less fat than the corresponding controls). This profile in Leu-females was associated with altered neuronal architecture at the paraventricular nucleus (PVN), involving neuropeptide Y (NPY) fibers and impaired expression of neuropeptides and factors of the mTOR signaling pathway in the hypothalamus. Interestingly, leptin and adiponectin expression in adipose tissue at weaning and at the time before the onset of obesity could be defined as early biomarkers of metabolic disturbance, predisposing towards adult obesity under the appropriate environment. Lopez N, Sánchez J, Palou Oliver A, Serra F. Gender-Associated Impact of Early Leucine Supplementation on Adult Predisposition to Obesity in Rats. Nutrients. 2018 Jan;10(1):76. 10.3390/nu10010076 2072-6643 Nutrients http://hdl.handle.net/20.500.13003/9467 29329236 L620304279 2-s2.0-85040947669 https://hdl.handle.net/20.500.12105/22573 424088000076 Leucine supplementation Metabolic imprinting Perinatal nutrition Obesity Biomarkers Gender-Associated Impact of Early Leucine Supplementation on Adult Predisposition to Obesity in Rats